Lakshmanan M, Mion L C, Frengley J D
J Am Geriatr Soc. 1986 Jun;34(6):421-6. doi: 10.1111/j.1532-5415.1986.tb03408.x.
The efficacy of low doses (10 to 20 mg daily) of doxepin in the treatment of depressive disorders in elderly inpatients was assessed by a double-blind study in 24 patients. The patients were treated for a three-week period to test for an early response. The Hamilton Depression Scale and the Geriatric Depression Scale were used to quantify symptoms of depression. The patients treated with doxepin had a significantly greater reduction in depressive symptoms than did those who received a placebo. No side effects were found and there were no major differences in the degree of physical dependency between the doxepin and placebo groups. A depressive disorder is a common occurrence among elderly inpatients and the effectiveness of low dose doxepin therapy without demonstrable side effects argues for the active treatment for this condition.
通过一项针对24名老年住院患者的双盲研究，评估了低剂量（每日10至20毫克）多塞平治疗老年住院患者抑郁症的疗效。患者接受了为期三周的治疗以测试早期反应。使用汉密尔顿抑郁量表和老年抑郁量表对抑郁症状进行量化。接受多塞平治疗的患者抑郁症状的减轻程度明显大于接受安慰剂的患者。未发现副作用，多塞平组和安慰剂组在身体依赖程度上没有重大差异。抑郁症在老年住院患者中很常见，低剂量多塞平治疗有效且无明显副作用，这为积极治疗这种疾病提供了依据。
