Titievsky J, Seco G, Barranco M, Kyle E M
J Clin Psychiatry. 1982 Nov;43(11):454-6.
Depression and anxiety can contribute to both drug dependence and reduced retention rates in methadone maintenance programs. In a 5-week double-blind study, the effectiveness of doxepin as an adjunctive treatment was compared to placebo in 46 depressed/anxious patients attending a methadone maintenance program. Doxepin was superior to placebo on Clinical Global Impressions and several factors of the Hamilton Rating Scale for Depression and the Profile of Mood States. No clinically significant potentiation of side effects was observed with the combined administration of doxepin and methadone.
抑郁和焦虑会导致药物依赖，并降低美沙酮维持治疗项目中的留存率。在一项为期5周的双盲研究中，将多塞平作为辅助治疗的有效性与安慰剂在46名参加美沙酮维持治疗项目的抑郁/焦虑患者中进行了比较。在临床总体印象以及汉密尔顿抑郁评定量表和情绪状态剖面图的几个因素方面，多塞平优于安慰剂。多塞平和美沙酮联合使用未观察到临床上显著的副作用增强。
