Hourizadeh Jason, Joy Justin, Berger Joseph I, Zainah Hanady
Internal Medicine, St. John's Riverside Hospital, Yonkers, USA.
Cureus. 2023 Mar 1;15(3):e35640. doi: 10.7759/cureus.35640. eCollection 2023 Mar.
We present a 73-year-old male with a history of end-stage renal disease (ESRD) on dialysis, type 2 diabetes mellitus, coronary artery disease status post stents, prostate carcinoma status post radiation, and prostatectomy, with recurrent bladder neck contracture requiring suprapubic catheter, left urethral stricture with nephrostomy tube placement, penile implant, and recurrent urinary tract infections, who presented to the emergency room complaining of constant bilateral groin pain for one day. Physical exam was significant for suprapubic tenderness and a chronic suprapubic catheter and left-sided nephrostomy tube. An initial examination of the patient's urine revealed turbid, yellow-colored fluid, positive for white blood cells, leukocyte esterase, and bacteria. A urine culture was obtained, which returned positive for with >100,000colony-forming units (CFUs)as well as demonstrating low colony counts. The patient was treated with a seven-day course of meropenem 1 gm twice daily, which improved of his symptoms, and then completed a 10-day course of ertapenem 500 mg daily. The patient received a five-day course of vancomycin 1 gm on dialysis days for additional coverage of , despite low colony counts. This is the first documented case of a urinary tract infection caused by . The organism is primarily found in immunocompromised individuals, and a debate is still ongoing as to whether it is a true pathogen or exists primarily as an opportunistic infection. We suggest further inquiry and study of this resistant organism are paramount in establishing its role in both immunocompromised as well as immunocompetent individuals. is a multidrug-resistant organism, which to date has sparse documentation regarding its prevalence and potential for morbidity, especially in compromised individuals. In the era of increasing antibiotic resistance, we suggest that more research is needed to understand the pathogenicity of .
我们报告一名73岁男性,有终末期肾病(ESRD)透析史、2型糖尿病、冠状动脉疾病支架置入术后、前列腺癌放疗及前列腺切除术后病史,反复出现膀胱颈挛缩需耻骨上导管引流,左侧尿道狭窄并放置肾造瘘管,有阴茎植入物,且反复发生尿路感染,因双侧腹股沟持续疼痛1天就诊于急诊室。体格检查发现耻骨上压痛明显,有一根慢性耻骨上导管和左侧肾造瘘管。对患者尿液的初步检查显示尿液浑浊、呈黄色,白细胞、白细胞酯酶及细菌检测均为阳性。进行了尿培养,结果显示菌落形成单位(CFU)>100,000且有低菌落计数的[具体细菌名称]呈阳性。患者接受了为期7天的美罗培南治疗,每日2次,每次1克,症状有所改善,随后完成了为期10天的厄他培南治疗,每日500毫克。尽管菌落计数较低,但患者在透析日接受了为期5天的万古霉素治疗,每日1克,以额外覆盖[具体细菌名称]。这是首例有记录的由[具体细菌名称]引起的尿路感染病例。该病原体主要见于免疫功能低下的个体,关于它是真正的病原体还是主要作为机会性感染存在,目前仍在争论中。我们认为,进一步探究和研究这种耐药菌对于明确其在免疫功能低下及免疫功能正常个体中的作用至关重要。[具体细菌名称]是一种多重耐药菌,迄今为止,关于其流行情况和发病潜力的文献资料稀少,尤其是在身体状况不佳的个体中。在抗生素耐药性不断增加的时代,我们认为需要更多研究来了解[具体细菌名称]的致病性。