relA基因座在支链氨基酸转运调节中指定一种正效应物。
The relA locus specifies a positive effector in branched-chain amino acid transport regulation.
作者信息
Quay S C, Oxender D L
出版信息
J Bacteriol. 1979 Feb;137(2):1059-62. doi: 10.1128/jb.137.2.1059-1062.1979.
Abstract
The regulation of branched-chain amino acid transport and periplasmic binding proteins was studied in Escherichia coli strains which were isogenic except for the relA locus, the gene for the "stringent factor," which is responsible for guanosine tetraphosphate synthesis. The strain containing the relA mutation could not be derepressed for the synthesis of leucine transport or binding proteins when shifted from a medium containing all 20 amino acids in excess to one in which leucine was limiting. The relA+ strain showed normal derepression under these conditions.
摘要
在除relA位点外基因完全相同的大肠杆菌菌株中，研究了支链氨基酸转运和周质结合蛋白的调控情况。relA位点是“应急因子”的基因，负责鸟苷四磷酸的合成。当从富含所有20种过量氨基酸的培养基转移到亮氨酸受限的培养基时，含有relA突变的菌株在亮氨酸转运蛋白或结合蛋白的合成方面无法实现去阻遏。在这些条件下，relA+菌株表现出正常的去阻遏现象。
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