Simonović I, Kargacin B, Kostial K
J Appl Toxicol. 1986 Apr;6(2):109-11. doi: 10.1002/jat.2550060208.
The efficiency of a composite oral treatment on 131I thyroid uptake was investigated in three adult volunteers. The treatment consisted of 10 g of calcium alginate, 3 g ferrihexacyanoferrate(II), 130 mg of potassium iodide and 5 g of Zn-DTPA. This mixture when administered 30 min before 131I almost completely blocked the 131I thyroid uptake. This indicates that simultaneous administration of other antidotal agents do not cancel or decrease the effect of potassium iodide on 131I thyroid uptake. The finding deserves attention since composite oral treatment is the recommended therapy in cases of accidental environmental exposure to several radionuclides.
在三名成年志愿者中研究了一种复合口服疗法对¹³¹I甲状腺摄取的效果。该疗法由10克海藻酸钙、3克亚铁氰化铁（II）、130毫克碘化钾和5克锌二乙三胺五乙酸组成。在¹³¹I给药前30分钟给予这种混合物几乎完全阻断了¹³¹I甲状腺摄取。这表明同时给予其他解毒剂不会消除或降低碘化钾对¹³¹I甲状腺摄取的作用。由于复合口服疗法是意外环境暴露于多种放射性核素情况下的推荐疗法，这一发现值得关注。
