Kostial K, Kargacin B, Simonović I
J Appl Toxicol. 1983 Dec;3(6):291-6. doi: 10.1002/jat.2550030604.
The effect of a composite antidotal treatment - consisting of a mixture of calcium alginate, ferrihexacyanoferrate(II) and potassium iodide - administered in diet and/or Na3(CaDTPA) administered intraperitoneally on the absorption and the removal of radioactive strontium, caesium, iodine and cerium was investigated in 7-week-old female rats. The animals were on respective treatments for 3 days. The retention of 141Ce, 85Sr, 137Cs and 131I was determined in the whole body, carcass, gut, liver, kidneys and respective critical organs (femur, muscle, thyroid) 6 days after their oral or intraperitoneal administration. In animals which received the antidotal mixture or Na3(CaDTPA) alone, the radionuclide retention was practically the same as in rats which were given the composite treatment [mixture + Na3(CaDTPA)]. This indicates that the efficiency of one treatment was not increased by the other. For 141Ce, Na3(CaDTPA) was an effective antidote, while 85Sr, 137Cs and 131I were reduced by the mixture. It is concluded that the composite treatment might be a quick treatment for choice for reducing mixed fission products retention, especially in cases when identification of exposure is difficult or impossible to make.
研究了在7周龄雌性大鼠中，通过饮食给予由海藻酸钙、亚铁氰化铁（II）和碘化钾组成的复合解毒剂，和/或腹腔注射Na3（CaDTPA），对放射性锶、铯、碘和铈的吸收及清除的影响。动物接受相应处理3天。在口服或腹腔注射141Ce、85Sr、137Cs和131I 6天后，测定全身、胴体、肠道、肝脏、肾脏及各个关键器官（股骨、肌肉、甲状腺）中这些放射性核素的滞留情况。在单独接受解毒剂混合物或Na3（CaDTPA）的动物中，放射性核素的滞留情况与接受复合处理（混合物+Na3（CaDTPA））的大鼠基本相同。这表明一种处理的效果不会因另一种处理而增强。对于141Ce，Na3（CaDTPA）是一种有效的解毒剂，而混合物可降低85Sr、137Cs和131I的滞留。结论是，复合处理可能是减少混合裂变产物滞留的快速首选处理方法，尤其是在难以或无法确定暴露情况的案例中。
