Duke University School of Medicine, Durham, North Carolina.
Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina.
Cancer Epidemiol Biomarkers Prev. 2023 Apr 3;32(4):473-486. doi: 10.1158/1055-9965.EPI-22-0994.
Gastric cancer, the fifth leading cause of cancer worldwide, is estimated to be responsible for approximately 1.4% of all new cancers and 1.8% of all cancer-related deaths in the United States. Despite declining incidence rates and improved survival rates, however, gastric cancer continues to disproportionately affect racial and ethnic minorities and individuals of lower socioeconomic status at higher rates than the general population. To improve outcomes globally and address disparities within the United States, continued improvements are needed in risk factor modification and biomarker development and to improve access to existing preventative measures such as genetic testing and H. pylori eradication testing, in addition to expanding upon current clinical guidelines for premalignant disease to address gaps in endoscopic surveillance and early detection.
胃癌是全球第五大致癌原因，据估计，它在美国约占所有新发癌症的 1.4%，占所有癌症相关死亡的 1.8%。然而，尽管发病率下降和生存率提高，胃癌仍然不成比例地影响着少数族裔和社会经济地位较低的人群，其发病率高于一般人群。为了在全球范围内改善结果并解决美国内部的差异，需要在危险因素的改变和生物标志物的开发方面持续改进，并改善获得现有预防措施的机会，例如基因检测和幽门螺杆菌根除检测，此外还需要扩展当前针对癌前疾病的临床指南，以解决内镜监测和早期发现方面的差距。
