Department of Stomatology, Medical School of Chinese PLA, 100853, Beijing, China.
Department of Stomatology, the First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
J Biomed Mater Res A. 2023 Sep;111(9):1358-1371. doi: 10.1002/jbm.a.37538. Epub 2023 Apr 3.
Due to its excellent biocompatibility and corrosion resistance, tantalum demonstrates versatility as an implant material. However, limited studies investigated the role of tantalum coated titanium-based dental implants. This study aimed to investigate the potential application of micro-nano porous structured tantalum coating on the surface of titanium dental implant. In the present study, micro-nano porous structured tantalum coating was prepared by vacuum plasma spraying (VPS) under selected optimum parameters, various characteristics of tantalum coating (Ta/Ti), including the morphology, potential, constituent, and hydrophilia, were investigated in comparison with its respective control groups, sandblasted titanium (Ti) and titanium coating (Ti/Ti). The adhesion, proliferation, and osteogenic differentiation ability of rat bone marrow mesenchymal cells (BMSCs) on different materials were assessed in vitro. Then the osseointegration capacity of Ti, Ti/Ti, Ta/Ti, and Straumann implants in canine mandible was evaluated with micro-CT, histological sections, and energy dispersive X-ray spectroscopy. These results demonstrated that micro-nanostructured, uneven, and granular tantalum coating was successfully prepared on titanium substrate by VPS with pore size ranging from 50 nm to 5 μm and thickness ranging from 80 to 100 μm. Tantalum coating revealed the highest surface potential, best hydrophilia, and most protein adsorption among Ta/Ti, Ti/Ti, and Ti. Furthermore, Ta/Ti surfaces significantly promoted the adhesion, proliferation, and osteogenic differentiation of BMSCs. In vivo, Ta/Ti implants displayed positive osseointegration capability associated with increased bone mineral density and formation of new bone around implants without tantalum particles released. Together, these findings indicate that tantalum-coated titanium dental implants may serve as a new type of dental implant.
由于其优异的生物相容性和耐腐蚀性，钽在作为植入物材料方面具有多功能性。然而，目前有限的研究探讨了涂覆钽的钛基牙科植入物的作用。本研究旨在研究表面涂覆微纳多孔结构钽对钛牙科植入物的潜在应用。在本研究中，通过真空等离子喷涂（VPS）在选定的最佳参数下制备微纳多孔结构的钽涂层，研究了包括形貌、电位、成分和润湿性在内的各种特性，并与各自的对照组（喷砂钛（Ti）和钛涂层（Ti/Ti）进行了比较。评估了不同材料上大鼠骨髓间充质细胞（BMSCs）的黏附、增殖和成骨分化能力。然后，通过 micro-CT、组织切片和能谱分析评估 Ti、Ti/Ti、Ta/Ti 和 Straumann 植入物在犬下颌骨中的骨整合能力。结果表明，通过 VPS 在钛基底上成功制备了具有 50nm 至 5μm 孔径和 80 至 100μm 厚度的微纳米结构、不均匀和颗粒状的钽涂层。Ta/Ti、Ti/Ti 和 Ti 中，钽涂层具有最高的表面电位、最佳的润湿性和最多的蛋白质吸附。此外，Ta/Ti 表面显著促进了 BMSCs 的黏附、增殖和成骨分化。体内，Ta/Ti 植入物表现出积极的骨整合能力，与植入物周围骨密度增加和新骨形成有关，没有释放钽颗粒。综上所述，这些发现表明涂覆钽的钛牙科植入物可能成为一种新型的牙科植入物。
