Najar Hemen, Karanti Alina, Pålsson Erik, Landén Mikael
Institute of Neuroscience and Physiology, Section of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Blå stråket 15, Gothenburg, 413 45, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Diabetol Metab Syndr. 2023 Apr 3;15(1):69. doi: 10.1186/s13098-023-01044-7.
We recently conducted the first longitudinal study comparing cardiometabolic risk indicators (CMRIs) between a cohort of individuals with bipolar disorders (BDs) and controls from the general population. Here, we sought to validate the findings in that study using an independent case-control sample.
We used data from the St. Göran project's Gothenburg cohort. The BDs group and the control group were examined at baseline and after a median of eight and seven years, respectively. Data collection occurred between March 2009 and June 2022. We used multiple imputation to handle missing data and linear mixed effects model to examine the annual change in CMRIs over the study period.
The baseline cohort included 407 individuals with BDs (mean age 40 years, 63% women) and 56 controls (mean age 43 years, 54% women). Of those, 63 persons with BDs and 42 controls participated at follow-up. At baseline, individuals with BDs had significantly higher mean values of body mass index (β = 0.14, p = 0.003) than controls. Over the study period, the difference in average annual change between the patient and the control group indicated an increase in patients relative to controls in waist-to-hip ratio (0.004 unit/year, p = 0.01), diastolic (0.6 mm Hg/year, p = 0.048), and systolic (0.8 mm Hg/year, p = 0.02) blood pressure.
This study replicated the main findings from our previous study and showed that central obesity and measures of blood pressure worsened over a relatively short time in individuals with BDs relative to controls. It is vital for clinicians to monitor CMRIs in persons with BDs and to be proactive in preventing cardiometabolic diseases in this high-risk group.
我们最近开展了第一项纵向研究，比较双相情感障碍（BD）患者队列与普通人群对照组之间的心脏代谢风险指标（CMRI）。在此，我们试图使用独立的病例对照样本验证该研究中的发现。
我们使用了圣戈兰项目哥德堡队列的数据。BD组和对照组分别在基线时以及中位数为8年和7年后接受检查。数据收集于2009年3月至2022年6月期间进行。我们使用多重填补法处理缺失数据，并使用线性混合效应模型来检查研究期间CMRI的年度变化。
基线队列包括407名BD患者（平均年龄40岁，63%为女性）和56名对照者（平均年龄43岁，54%为女性）。其中，63名BD患者和42名对照者参与了随访。在基线时，BD患者的体重指数平均值（β = 0.14，p = 0.003）显著高于对照组。在研究期间，患者组与对照组的年均变化差异表明，患者相对于对照组的腰臀比（0.004单位/年，p = 0.01）、舒张压（0.6毫米汞柱/年，p = 0.048）和收缩压（0.8毫米汞柱/年，p = 0.02）有所增加。
本研究重复了我们先前研究的主要发现，并表明与对照组相比，BD患者在相对较短的时间内中心性肥胖和血压指标恶化。临床医生监测BD患者的CMRI并积极预防这一高危人群的心脏代谢疾病至关重要。
