Landén Mikael, Jonsson Lina, Klahn Anna Luisa, Kardell Mathias, Göteson Andreas, Abé Christoph, Aspholmer Andreas, Liberg Benny, Pelanis Aurimantas, Sparding Timea, Pålsson Erik
Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Neuropsychobiology. 2025;84(2):86-99. doi: 10.1159/000543335. Epub 2025 Jan 2.
The St. Göran Bipolar Project (SBP) is a longitudinal outpatient study investigation aimed at identifying predictive factors associated with long-term outcomes in individuals with bipolar disorder. These outcomes include cognitive function, relapse rate, treatment responses, and functional outcomes. The study employs a multifaceted approach, integrating brain imaging, biochemical analyses of cerebrospinal fluid and blood, and genetics. This paper provides an overview of the research methods used in the SBP, along with a summary of the main findings to date.
SBP is a collaborative effort between academia and healthcare, enrolling study participants from bipolar outpatient clinics in Stockholm (SBP-S) and Gothenburg (SBP-G), Sweden. Healthy controls were recruited through Statistics Sweden. Data and samples were collected using structured interviews, self-rated questionnaires, blood and cerebrospinal fluid samples, magnetic resonance imaging, and neuropsychological tests. Follow-up visits are conducted 7 and 14 years after baseline.
The SBP has generated numerous original findings and has contributed to advancing knowledge on cognitive function, personality, cerebrospinal and blood biomarkers, neuroimaging, and genetics. Further, as data collection nears completion, new research questions can be addressed. The study's strengths include detailed, multimodal information from each study visit and a long follow-up period. The naturalistic setting ensures that findings are relevant to real-world scenarios. However, variability in data completeness can introduce selection bias. Additionally, the control population, while randomly selected, may not be fully representative due to the voluntary nature of participation. Future projects will focus on longitudinal analyses and novel methods to exploit the study's multifaceted approach.
The St. Göran Bipolar Project (SBP) is a longitudinal outpatient study investigation aimed at identifying predictive factors associated with long-term outcomes in individuals with bipolar disorder. These outcomes include cognitive function, relapse rate, treatment responses, and functional outcomes. The study employs a multifaceted approach, integrating brain imaging, biochemical analyses of cerebrospinal fluid and blood, and genetics. This paper provides an overview of the research methods used in the SBP, along with a summary of the main findings to date.
SBP is a collaborative effort between academia and healthcare, enrolling study participants from bipolar outpatient clinics in Stockholm (SBP-S) and Gothenburg (SBP-G), Sweden. Healthy controls were recruited through Statistics Sweden. Data and samples were collected using structured interviews, self-rated questionnaires, blood and cerebrospinal fluid samples, magnetic resonance imaging, and neuropsychological tests. Follow-up visits are conducted 7 and 14 years after baseline.
The SBP has generated numerous original findings and has contributed to advancing knowledge on cognitive function, personality, cerebrospinal and blood biomarkers, neuroimaging, and genetics. Further, as data collection nears completion, new research questions can be addressed. The study's strengths include detailed, multimodal information from each study visit and a long follow-up period. The naturalistic setting ensures that findings are relevant to real-world scenarios. However, variability in data completeness can introduce selection bias. Additionally, the control population, while randomly selected, may not be fully representative due to the voluntary nature of participation. Future projects will focus on longitudinal analyses and novel methods to exploit the study's multifaceted approach.
圣戈兰双相情感障碍项目（SBP）是一项纵向门诊研究调查，旨在确定与双相情感障碍患者长期预后相关的预测因素。这些预后包括认知功能、复发率、治疗反应和功能结局。该研究采用多方面的方法，整合了脑成像、脑脊液和血液的生化分析以及遗传学。本文概述了SBP中使用的研究方法，以及迄今为止的主要研究结果总结。
SBP是学术界与医疗保健机构的合作项目，从瑞典斯德哥尔摩（SBP-S）和哥德堡（SBP-G）的双相情感障碍门诊诊所招募研究参与者。健康对照通过瑞典统计局招募。使用结构化访谈、自评问卷、血液和脑脊液样本、磁共振成像以及神经心理学测试收集数据和样本。在基线后7年和14年进行随访。
SBP产生了许多原创性研究结果，并有助于推进关于认知功能、人格、脑脊液和血液生物标志物、神经成像以及遗传学的知识。此外，随着数据收集接近完成，可以解决新的研究问题。该研究的优势包括每次研究访视提供的详细多模态信息以及较长的随访期。自然主义的环境确保研究结果与现实世界的情况相关。然而，数据完整性的差异可能会引入选择偏差。此外，尽管对照人群是随机选择的，但由于参与的自愿性质，可能并不完全具有代表性。未来的项目将侧重于纵向分析以及利用该研究多方面方法的新方法。
圣戈兰双相情感障碍项目（SBP）是一项纵向门诊研究调查，旨在确定与双相情感障碍患者长期预后相关的预测因素。这些预后包括认知功能、复发率、治疗反应和功能结局。该研究采用多方面的方法，整合了脑成像、脑脊液和血液的生化分析以及遗传学。本文概述了SBP中使用的研究方法，以及迄今为止的主要研究结果总结。
SBP是学术界与医疗保健机构的合作项目，从瑞典斯德哥尔摩（SBP-S）和哥德堡（SBP-G）的双相情感障碍门诊诊所招募研究参与者。健康对照通过瑞典统计局招募。使用结构化访谈、自评问卷、血液和脑脊液样本、磁共振成像以及神经心理学测试收集数据和样本。在基线后7年和14年进行随访。
SBP产生了许多原创性研究结果，并有助于推进关于认知功能、人格、脑脊液和血液生物标志物、神经成像以及遗传学的知识。此外，随着数据收集接近完成，可以解决新的研究问题。该研究的优势包括每次研究访视提供的详细多模态信息以及较长的随访期。自然主义的环境确保研究结果与现实世界的情况相关。然而，数据完整性的差异可能会引入选择偏差。此外，尽管对照人群是随机选择的，但由于参与的自愿性质，可能并不完全具有代表性。未来的项目将侧重于纵向分析以及利用该研究多方面方法的新方法。
