Institute of Microscale Optoelectronics and College of Electronics and Information Engineering, Shenzhen University, Shenzhen, 518060, P. R. China.
Institute for Advanced Study, Shenzhen University, Shenzhen, 518060, P. R. China.
Small. 2023 Jul;19(27):e2207879. doi: 10.1002/smll.202207879. Epub 2023 Apr 3.
Human beings have a greater need to pursue life and manage personal or family health in the context of the rapid growth of artificial intelligence, big data, the Internet of Things, and 5G/6G technologies. The application of micro biosensing devices is crucial in connecting technology and personalized medicine. Here, the progress and current status from biocompatible inorganic materials to organic materials and composites are reviewed and the material-to-device processing is described. Next, the operating principles of pressure, chemical, optical, and temperature sensors are dissected and the application of these flexible biosensors in wearable/implantable devices is discussed. Different biosensing systems acting in vivo and in vitro, including signal communication and energy supply are then illustrated. The potential of in-sensor computing for applications in sensing systems is also discussed. Finally, some essential needs for commercial translation are highlighted and future opportunities for flexible biosensors are considered.
在人工智能、大数据、物联网和 5G/6G 技术快速发展的背景下，人类更加需要追求生命和管理个人或家庭健康。微生物传感设备的应用对于连接技术和个性化医疗至关重要。在这里，我们回顾了从生物相容无机材料到有机材料和复合材料的进展和现状，并描述了材料到器件的处理过程。接下来，我们剖析了压力、化学、光学和温度传感器的工作原理，并讨论了这些柔性生物传感器在可穿戴/植入式设备中的应用。然后，我们展示了不同的生物传感系统在体内和体外的作用，包括信号通信和能量供应。我们还讨论了传感器内计算在传感系统中的应用潜力。最后，我们强调了一些对于商业转化的基本需求，并考虑了柔性生物传感器的未来机遇。
