Torlińska T, Rutkowska D, Hryniewiecki T, Paluszak J
Department of Physiology, Poznań Academy of Medicine.
Acta Physiol Pol. 1990 Nov-Dec;41(7):76-84.
The present report indicates that 2-deoxy-D-glucose (2-DG) at a single dose causing reduction of Tre has no influence on liver and skeletal muscle content of ATP, ADP and AMP, the ATP/ADP ratio, energy charge potential (ECP) and total adenine nucleotides (TAN). After administration of 2-DG for 3) successive days, the level of ATP, ATP/ADP ratio, the values of ECP and TAN are decreased both in the liver and skeletal muscle. However, 72 hours after the last injection of 2-DG adenine nucleotide contents returned to the values observed in control group, indicating that the in vivo effect of this glucose analogue is fully reversible.
本报告表明，单剂量引起Tre降低的2-脱氧-D-葡萄糖（2-DG）对肝脏和骨骼肌中ATP、ADP和AMP的含量、ATP/ADP比值、能荷电位（ECP）和总腺嘌呤核苷酸（TAN）没有影响。连续3天给予2-DG后，肝脏和骨骼肌中ATP水平、ATP/ADP比值、ECP值和TAN均降低。然而，在最后一次注射2-DG 72小时后，腺嘌呤核苷酸含量恢复到对照组观察到的值，表明这种葡萄糖类似物的体内作用是完全可逆的。
