ODESA NATIONAL MEDICAL UNIVERSITY, ODESA, UKRAINE; CITY DENTAL CLINIC 3, ODESA, UKRAINE.
ODESA NATIONAL MEDICAL UNIVERSITY, ODESA, UKRAINE.
Wiad Lek. 2023;76(2):377-385. doi: 10.36740/WLek202302119.
The aim: To analyze the state of periodontal tissues against the background of Helicobacter pylori invasion in dynamics and to propose a possible mechanism of development of inflammatory periodontal diseases in patients with Helicobacter pylori-associated pathology of the gastrointestinal tract.
Materials and methods: We examined 43 patients with Helicobacter pylori-associated gastrointestinal pathology and 42 patients of the same age without somatic pathology, including without gastrointestinal pathology associated with Helicobacter pylori. Clinical and laboratory research methods (clinical, instru-mental, biochemical, histological methods) were used.
Results: Comparing the data of clinical observations and the results of laboratory studies of patients with inflammatory periodontal disease on the background of Helicobacter pylori-associated gastrointestinal pathology, obtained in different observation periods, we can assume that basic dental treatment of periodontal disease in such patients undergoing eradication therapy does not provide stable anti-inflammatory, antimicrobial and antioxidant effect, which leads to reduced periods of remission and recurrence of periodontal disease, where oral dysbiosis plays a crucial role.
Conclusions: Comparing the data of clinical observations and the results of laboratory studies of patients with chronic gingivitis on the background of Helicobacter pylori-associated gastrointestinal pathology, obtained in different observation periods, we can say that they correlate with each other and suggest that the basic dental treatment of chronic gingivatis on the background of H.pylori-associated pathology of the gastrointestinal tract, which is currently undergoing a course of eradication, does not give a stable anti-inflammatory, antimicrobial and antioxidant effect, which leads to recurrence of periodontal disease and shortening remission periods, where oral dysbiosis plays a crucial role.
分析在幽门螺杆菌侵袭背景下牙周组织的动态状态，并提出幽门螺杆菌相关胃肠道病理患者发生炎症性牙周病的可能发展机制。
我们检查了 43 例幽门螺杆菌相关胃肠道病理患者和 42 例年龄相同、无躯体病理（包括无与幽门螺杆菌相关的胃肠道病理）的患者。采用临床和实验室研究方法（临床、仪器、生化、组织学方法）。
比较幽门螺杆菌相关胃肠道病理患者炎症性牙周病的临床观察数据和不同观察期实验室研究结果，我们可以假设，在根除治疗中，此类患者的牙周病基本牙科治疗不能提供稳定的抗炎、抗菌和抗氧化作用，这导致牙周病缓解期和复发期缩短，其中口腔菌群失调起着至关重要的作用。
比较幽门螺杆菌相关胃肠道病理患者慢性牙龈炎的临床观察数据和不同观察期实验室研究结果，可以说它们相互关联，并表明目前正在进行根除治疗的幽门螺杆菌相关胃肠道病理背景下慢性牙龈炎的基本牙科治疗不能提供稳定的抗炎、抗菌和抗氧化作用，导致牙周病复发和缓解期缩短，其中口腔菌群失调起着至关重要的作用。
