Liu Qinghua, Zhang Ying, Qi Fengxiang
Peking University Health Science Center, Beijing, China.
Department of Gastroenterology, The Second Hospital of Tianjin Medical University, 23 Pingjiang Road, Tianjin 300211, People's Republic of China.
Int Dent J. 2025 Jun;75(3):1510-1521. doi: 10.1016/j.identj.2024.12.027. Epub 2025 Mar 22.
Helicobacter pylori (Hp) infection has been implicated in both gastric and extra-gastric diseases, including periodontitis.
This meta-analysis investigated the association between Helicobacter pylori (Hp) infection and periodontitis by systematically reviewing eight studies. The analysis was conducted using the R package "meta," employing both fixed effects and random effects models. The level of heterogeneity among the studies was assessed using the I-squared statistic and tau values. Publication bias was evaluated through funnel plots, Begg's rank correlation, and Egger's regression tests to ensure the robustness of the findings.
The meta-analysis included a total of 6061 observations, with 1404 cases of periodontitis. The fixed effects model produced an odds ratio (OR) of 2.3392 (95% confidence interval [CI]: 2.0207-2.7078), and the random effects model yielded a similar OR of 2.3220 (95% CI: 2.0050-2.6892). The I-squared statistic indicated low to moderate heterogeneity among the studies. Subgroup analyses demonstrated consistent associations across different Hp diagnostic methods.
Hp infection is significantly associated with an increased risk of periodontitis, highlighting its role in both gastric and oral health.
幽门螺杆菌（Hp）感染与包括牙周炎在内的胃部和胃外疾病有关。
本荟萃分析通过系统回顾八项研究，调查了幽门螺杆菌（Hp）感染与牙周炎之间的关联。使用R包“meta”进行分析，采用固定效应模型和随机效应模型。使用I²统计量和tau值评估研究之间的异质性水平。通过漏斗图、Begg秩相关检验和Egger回归检验评估发表偏倚，以确保研究结果的稳健性。
荟萃分析共纳入6061例观察对象，其中牙周炎患者1404例。固定效应模型得出的比值比（OR）为2.3392（95%置信区间[CI]：2.0207 - 2.7078），随机效应模型得出的类似OR为2.3220（95%CI：2.0050 - 2.6892）。I²统计量表明研究之间存在低到中度的异质性。亚组分析表明，不同Hp诊断方法之间的关联一致。
Hp感染与牙周炎风险增加显著相关，凸显了其在胃部和口腔健康中的作用。
