UNIVERSITY OF KUFA, AL.-NAJAF, IRAQ.
ALSADER TEACHING HOSPITAL, AL-NAJAF, IRAQ.
Wiad Lek. 2023;76(2):406-414. doi: 10.36740/WLek202302123.
1 UNIVERSITY OF KUFA, AL.-NAJAF, IRAQ 2ALSADER TEACHING HOSPITAL, AL!NAJAF, IRAQ The aim: To research the association of H. pylori infection in patients with irritable bowel syndrome.
Materials and method: In this case control study, 43 patients with IBS (13 males and 30 females) diagnosed according to Rome IV criteria and other 43 controls where included, the patients and control are matched to the gender and age which ranged from 18 to55 years, the study groups were referred to perform a stool antigen test for H. pylori.
Results: Presence of H. pylori was compared between patients with IBS and controls using chi-square test. There was significant correlation between the presence of H. pylori and IBS, chi-square = 4.09, P-value = 0.043. The odd ratio for patients with H. pylori to have IBS was 2.53 (95% confidence interval: 1.02- 6.29). There is no signi"cant relationship between type of IBS and presence of H. pylori, chi-square = 2.87, P-value = 0.238. There is no significant relationship between the presence of H. pylori and age, BMI, gender, occupation, or marital state.
Conclusions: Results of our study had shown an association of H. pylori infection in patients with IBS, which may propose a link of this infection in IBS pathophysiology.
材料和方法：在这项病例对照研究中，43 名符合罗马 IV 标准诊断的肠易激综合征患者（13 名男性和 30 名女性）和 43 名对照组纳入研究，患者和对照组按性别和年龄匹配，年龄范围为 18 至 55 岁。研究组被要求进行粪便抗原检测以确定是否存在幽门螺杆菌。
结果：使用卡方检验比较肠易激综合征患者和对照组中幽门螺杆菌的存在情况。幽门螺杆菌的存在与肠易激综合征之间存在显著相关性，卡方=4.09，P 值=0.043。幽门螺杆菌阳性患者患肠易激综合征的比值比为 2.53（95%置信区间：1.02-6.29）。肠易激综合征的类型与幽门螺杆菌的存在之间没有显著关系，卡方=2.87，P 值=0.238。幽门螺杆菌的存在与年龄、BMI、性别、职业或婚姻状况之间没有显著关系。
结论：我们的研究结果表明幽门螺杆菌感染与肠易激综合征患者之间存在关联，这可能提示这种感染与肠易激综合征的病理生理学有关。
