Kondo Masaru, Nakamura Kento, Krishnan Chandu G, Sasai Hiroaki, Takizawa Shinobu
Department of Materials Science and Engineering, Graduate School of Science and Engineering, Ibaraki University, Hitachi-shi, Ibaraki, 316-8511, Japan.
SANKEN, Osaka University Mihogaoka, Ibaraki-shi, Osaka, 567-0047, Japan.
Chem Rec. 2023 Jul;23(7):e202300040. doi: 10.1002/tcr.202300040. Epub 2023 Apr 3.
This study presents recent advances in photoswitchable chiral organocatalysts and their applications in the photomodulation of enantioselective reactions. Under irradiation with an appropriate wavelength of light, the E/Z-photoisomerization of the photoresponsive units on the catalysts leads to the control of the catalytic activity and/or selectivity of the enantioselective reactions. Additionally, this study elucidates the design, synthesis, and catalytic application of the fabricated azobenzene BINOL-based photoswitchable chiral phase-transfer catalysts. This account will provide insights into the appropriate design of a photoswitchable chiral organocatalyst that can achieve both good enantioselectivity and photocontrol.
本研究介绍了光开关手性有机催化剂的最新进展及其在对映选择性反应光调制中的应用。在适当波长的光照射下，催化剂上光响应单元的E/Z光异构化导致对映选择性反应的催化活性和/或选择性得到控制。此外，本研究阐明了所制备的基于偶氮苯联萘酚的光开关手性相转移催化剂的设计、合成及催化应用。本综述将为设计出既能实现良好对映选择性又能实现光控的光开关手性有机催化剂提供见解。
