Developmental Psychology, University of Amsterdam, Amsterdam, The Netherlands.
Research Institute of Child Development and Education, University of Amsterdam, Amsterdam, The Netherlands.
Clin Child Fam Psychol Rev. 2023 Jun;26(2):416-429. doi: 10.1007/s10567-023-00432-9. Epub 2023 Apr 3.
The effectiveness of interventions for internalizing disorders in children and adolescents was studied using a review and meta-analysis of published single-case research. Databases and other resources were searched for quantitative single-case studies in youth with anxiety, depressive, and posttraumatic stress disorders. Raw data from individual cases were aggregated and analyzed by means of multilevel meta-analytic models. Outcome variables were symptom severity assessed across baseline and treatment phases of the studies, and diagnostic status at post- and follow-up treatment. Single-case studies were rated for quality. We identified 71 studies including 321 cases (M = 10.66 years; 55% female). The mean quality of the studies was rated as below average, although there were considerable differences between the studies. Overall, positive within-person changes during the treatment phase in comparison to the baseline phase were found. In addition, positive changes in the diagnostic status were observed at post- and follow-up treatment. Yet high variability in treatment effects was found between cases and studies. This meta-analysis harvests the knowledge from published single-case research in youth-internalizing disorders and illustrates how within-person information from single-case studies can be summarized to explore the generalizability of the results from this type of research. The results emphasize the importance of keeping account of individual variability in providing and investigating youth interventions.
本研究采用发表的单病例研究的综述和荟萃分析，研究了干预儿童和青少年内化障碍的效果。通过数据库和其他资源搜索了青少年焦虑症、抑郁症和创伤后应激障碍的定量单病例研究。通过多级荟萃分析模型汇总和分析了个体病例的原始数据。结果变量为研究的基线和治疗阶段的症状严重程度评估，以及治疗后和随访时的诊断状态。对单病例研究进行了质量评估。我们确定了 71 项研究，包括 321 个案例（M=10.66 岁；55%为女性）。研究的平均质量被评为低于平均水平，尽管研究之间存在相当大的差异。总体而言，与基线阶段相比，治疗阶段的个体内变化呈阳性。此外，在治疗后和随访时观察到诊断状态的积极变化。然而，病例和研究之间的治疗效果存在很大的可变性。这项荟萃分析从发表的青少年内化障碍的单病例研究中获取了知识，并说明了如何总结单病例研究的个体内信息，以探索这种类型研究结果的普遍性。结果强调了在提供和调查青少年干预措施时考虑个体变异性的重要性。
