Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China (mainland).
Center for Single-Cell Omics and Tumor Liquid Biopsy, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China (mainland).
Am J Case Rep. 2023 Apr 3;24:e939095. doi: 10.12659/AJCR.939095.
BACKGROUND Acute aortic occlusion (AAO) is a rare emergency with high mortality. The typical clinical presentation is the sudden appearance of pain, paralysis, sensory disturbances, and mottling of the lower extremities. The etiology of AAO can be broadly classified into 3 categories: in situ thrombosis, arterial embolism, and occlusion of grafts. AAO is a rare consequence of myocardial infarction in the era of anticoagulation therapy, as part of the management of acute coronary syndrome (ACS). CASE REPORT We report the case of a 65-year-old woman who presented with acute lower extremity pain and weakness after a myocardial infarction 2 weeks earlier. She was on standardized antiplatelet therapy, a high blood D-dimer level was found during a visit to the Emergency Department, a left ventricular mural thrombus was detected using bedside ultrasound, and computed tomography angiography revealed thrombotic occlusion of the abdominal aorta. AAO disease was diagnosed, but the patient refused further treatment and died after 7 days of follow-up. CONCLUSIONS In recent years, anticoagulation has become part of the standard of care for patients with myocardial infarction or atrial fibrillation, which has led to a lower incidence of arterial embolism leading to AAO than in situ thrombosis. Depending on the type of occlusion, there are also differences in the surgical approach. A computed tomography angiography of the abdomen should be performed on all patients in whom AAO cannot be ruled out. Timely diagnosis and prompt surgical intervention are essential to preventing mortality.
急性主动脉闭塞(AAO)是一种罕见的高死亡率急症。典型的临床表现是下肢突然出现疼痛、瘫痪、感觉障碍和斑驳。AAO 的病因可大致分为 3 类:原位血栓形成、动脉栓塞和移植物闭塞。AAO 是抗凝治疗时代心肌梗死的罕见后果,作为急性冠状动脉综合征(ACS)管理的一部分。
我们报告了一例 65 岁女性的病例,她在 2 周前心肌梗死后出现急性下肢疼痛和无力。她正在接受标准化抗血小板治疗,在急诊科就诊时发现血液 D-二聚体水平升高,床边超声检查发现左心室壁血栓,计算机断层血管造影显示腹主动脉血栓闭塞。诊断为 AAO 病,但患者拒绝进一步治疗,在随访 7 天后死亡。
近年来,抗凝治疗已成为心肌梗死或心房颤动患者标准治疗的一部分,这导致动脉栓塞导致 AAO 的发生率低于原位血栓形成。根据闭塞类型,手术方法也存在差异。对于所有不能排除 AAO 的患者,均应进行腹部计算机断层血管造影检查。及时诊断和及时手术干预对于预防死亡率至关重要。