Institute of Food Chemistry, Westfälische Wilhelms-Universität, Münster, Germany.
Special Analytical Services, Chemical and Veterinary, Analytical Institute Münsterland-Emscher-Lippe-AöR, Münster, Germany.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2023 May;40(5):667-674. doi: 10.1080/19440049.2023.2195954. Epub 2023 Apr 3.
This study describes the analysis of five quinolizidine alkaloids (QA), i.e. 13-OH-lupanine, lupanine, lupinine, angustifoline and sparteine in 30 samples of lupine flours, lupine seeds and derived products collected 2019-2021 on the German retail market. QA occur as secondary metabolites in plants of lupine species. Certain QA are of toxicological relevance. The analytical determination performed by LC-MS/MS revealed some samples with high QA concentrations (up to 21,000 mg/kg), particularly in bitter lupine seeds. As those concentrations would result in substantial exceedances of the maximum tolerable intake values proposed by health authorities, they must be considered as a health concern.
本研究分析了在德国零售市场上 2019 年至 2021 年采集的 30 份羽扇豆粉、羽扇豆种子及其衍生产品中的 5 种喹诺里西啶生物碱（QA），即 13-OH-羽扇豆碱、羽扇豆碱、羽扇豆宁、安托菲林和斯帕丁。QA 作为羽扇豆属植物中的次生代谢物存在。某些 QA 具有毒理学相关性。通过 LC-MS/MS 进行的分析测定显示，某些样品中的 QA 浓度很高（高达 21000mg/kg），特别是在苦羽扇豆种子中。由于这些浓度会导致超出卫生当局建议的最大耐受摄入量值，因此必须将其视为健康隐患。
