Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Poland.
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Poland; NeuroOncology Laboratory, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland.
Life Sci. 2023 Jun 1;322:121650. doi: 10.1016/j.lfs.2023.121650. Epub 2023 Apr 1.
GDF11 (Growth differentiation factor 11) is a newly discovered member of family of transforming growth factors-β. Its crucial role was confirmed in physiology, i.e. embryogenesis due to its involvement in bone formation, skeletogenesis and it is essential to stating skeletal pattern. GDF11 is described as a rejuvenating and anti-aging molecule, that could even restore functions. Beside embryogenesis, GDF11 participates in the process of inflammation and carcinogenesis. An anti-inflammatory effect of GDF11 was found in experimental colitis, psoriasis and arthritis. Current data regarding liver fibrosis and renal injury indicate that GDF11 may act as pro-inflammatory agent. In this review, we describe its involvement in regulation of acute and chronic inflammatory disorders.
生长分化因子 11（Growth differentiation factor 11，GDF11）是转化生长因子-β家族中一个新发现的成员。它在生理学中的关键作用已得到证实，即在胚胎发生过程中，由于其参与骨形成、骨骼发生，因此对骨骼形态的形成至关重要。GDF11 被描述为一种具有抗衰老和恢复功能的分子。除了胚胎发生，GDF11 还参与炎症和癌变过程。在实验性结肠炎、银屑病和关节炎中发现了 GDF11 的抗炎作用。目前关于肝纤维化和肾损伤的数据表明，GDF11 可能作为促炎剂发挥作用。在这篇综述中，我们描述了它在调节急性和慢性炎症性疾病中的作用。
