Laser and Optoelectronics Engineering Department, University of Technology-Iraq, Baghdad, Iraq.
Department of Physics, College of Science, University of Baghdad, Baghdad, Iraq.
Sci Rep. 2023 Apr 3;13(1):5441. doi: 10.1038/s41598-023-32330-z.
Given their versatile nature and wide range of possible applications, core-shell nanoparticles (NPs) have received considerable attention. This paper proposes a novel method for synthesizing ZnO@NiO core-shell nanoparticles using a hybrid technique. The characterization demonstrates the successful formation of ZnO@NiO core-shell nanoparticles, which have an average crystal size of 13.059 nm. The results indicate that the prepared NPs have excellent antibacterial activity against both Gram-negative and Gram-positive bacteria. This behavior is primarily caused by the accumulation of ZnO@NiO NPs on the bacteria's surface, which results in cytotoxic bacteria and a relatively increased ZnO, resulting in cell death. Moreover, the use of a ZnO@NiO core-shell material will prevent the bacteria from nourishing themselves in the culture medium, among many other reasons. Finally, the PLAL is an easily scalable, cost-effective, and environmentally friendly method for the synthesis of NPs, and the prepared core-shell NPs could be used in other biological applications such as drug delivery, cancer treatment, and further biomedical functionalization.
由于其多功能性和广泛的应用可能性，核壳纳米粒子（NPs）受到了相当大的关注。本文提出了一种使用混合技术合成 ZnO@NiO 核壳纳米粒子的新方法。表征结果表明成功合成了 ZnO@NiO 核壳纳米粒子，其平均晶体尺寸为 13.059nm。结果表明，所制备的 NPs 对革兰氏阴性和革兰氏阳性细菌均具有优异的抗菌活性。这种行为主要是由于 ZnO@NiO NPs 在细菌表面的积累，导致细胞毒性细菌和相对增加的 ZnO，从而导致细胞死亡。此外，使用 ZnO@NiO 核壳材料将阻止细菌在培养基中自我滋养，这是其中的许多原因之一。最后，PLAL 是一种易于扩展、具有成本效益且环保的 NPs 合成方法，所制备的核壳 NPs 可用于其他生物应用，如药物输送、癌症治疗和进一步的生物医学功能化。
