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F-FDG PET/CT imaging of posttransplant lymphoproliferative disorder following renal transplantation: Three clinical cases.肾移植后移植后淋巴增殖性疾病的F-FDG PET/CT成像：三例临床病例
Heliyon. 2023 Mar 22;9(4):e14746. doi: 10.1016/j.heliyon.2023.e14746. eCollection 2023 Apr.
2
F-FDG PET/CT in the Diagnostic and Treatment Evaluation of Pediatric Posttransplant Lymphoproliferative Disorders.氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描在儿科移植后淋巴增殖性疾病的诊断和治疗评估中的应用。
J Nucl Med. 2020 Sep;61(9):1307-1313. doi: 10.2967/jnumed.119.239624. Epub 2020 Jan 31.
3
(18)F-FDG PET/CT in the management of patients with post-transplant lymphoproliferative disorder.（18）氟代脱氧葡萄糖正电子发射断层显像/计算机断层扫描在移植后淋巴增殖性疾病患者管理中的应用
Nucl Med Commun. 2014 Mar;35(3):276-81. doi: 10.1097/MNM.0000000000000050.
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Hodgkin lymphoma post-transplant lymphoproliferative disorder following pediatric renal transplant: serial imaging with F-18 FDG PET/CT.儿童肾移植后霍奇金淋巴瘤移植后淋巴组织增生性疾病：F-18 FDG PET/CT 的连续影像学检查。
Clin Nucl Med. 2010 Sep;35(9):704-5. doi: 10.1097/RLU.0b013e3181e9fb87.
5
The value of 18F-FDG PET in pediatric patients with post-transplant lymphoproliferative disorder at initial diagnosis.18F-FDG PET在移植后淋巴细胞增生性疾病初诊儿科患者中的价值。
Pediatr Transplant. 2015 Dec;19(8):932-9. doi: 10.1111/petr.12611. Epub 2015 Oct 30.
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Clinical usefulness of FDG-PET/CT scan imaging in the management of posttransplant lymphoproliferative disease.氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG-PET/CT）成像在移植后淋巴增殖性疾病管理中的临床应用价值
Transplantation. 2008 Mar 15;85(5):707-12. doi: 10.1097/TP.0b013e3181661676.
7
Diagnostic performance of FDG-PET/CT of post-transplant lymphoproliferative disorder and factors affecting diagnostic yield.移植后淋巴组织增生性疾病的 FDG-PET/CT 诊断性能及影响诊断产量的因素。
Eur J Nucl Med Mol Imaging. 2020 Mar;47(3):529-536. doi: 10.1007/s00259-019-04481-7. Epub 2019 Aug 24.
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Performance of advanced imaging modalities at diagnosis and treatment response evaluation of patients with post-transplant lymphoproliferative disorder: A systematic review and meta-analysis.移植后淋巴组织增生性疾病患者的诊断和治疗反应评估中高级影像学方法的性能：系统评价和荟萃分析。
Crit Rev Oncol Hematol. 2018 Dec;132:27-38. doi: 10.1016/j.critrevonc.2018.09.007. Epub 2018 Sep 19.
9
Posttransplant Lymphoproliferative Disorder of the Thorax: CT and FDG-PET Features in a Single Tertiary Referral Center.胸部移植后淋巴组织增生性疾病：单一三级转诊中心的CT和FDG-PET特征
Medicine (Baltimore). 2015 Aug;94(31):e1274. doi: 10.1097/MD.0000000000001274.
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End-of-Treatment Positron Emission Tomography After Uniform First-Line Therapy of B-Cell Posttransplant Lymphoproliferative Disorder Identifies Patients at Low Risk of Relapse in the Prospective German PTLD Registry.一线治疗后 B 细胞移植后淋巴组织增生性疾病的正电子发射断层扫描预测前瞻性德国 PTLD 登记处复发低危患者。
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A New Era for PET/CT: Applications in Non-Tumorous Renal Pathologies.PET/CT的新时代：在非肿瘤性肾脏疾病中的应用
J Clin Med. 2024 Aug 7;13(16):4632. doi: 10.3390/jcm13164632.

本文引用的文献

1
Early- and late-onset posttransplant lymphoproliferative disorders among adult kidney and liver transplant recipients.成人肾和肝移植受者的移植后早期和晚期淋巴增生性疾病。
Eur J Haematol. 2022 Oct;109(4):343-350. doi: 10.1111/ejh.13815. Epub 2022 Jul 14.
2
Non-Hodgkin lymphoma after pediatric kidney transplantation.儿童肾移植后非霍奇金淋巴瘤。
Pediatr Nephrol. 2022 Aug;37(8):1759-1773. doi: 10.1007/s00467-021-05205-6. Epub 2021 Oct 11.
3
Epstein-Barr virus-associated monomorphic post-transplant lymphoproliferative disorder after pediatric kidney transplantation: A case report.小儿肾移植后 Epstein-Barr 病毒相关单形性移植后淋巴组织增生性疾病：一例报告
World J Clin Cases. 2021 Jan 16;9(2):469-475. doi: 10.12998/wjcc.v9.i2.469.
4
Semi-Quantitative Characterization of Post-Transplant Lymphoproliferative Disorder Morphological Subtypes with [F]FDG PET/CT.利用[F]FDG PET/CT对移植后淋巴细胞增生性疾病形态学亚型进行半定量特征分析。
J Clin Med. 2021 Jan 19;10(2):361. doi: 10.3390/jcm10020361.
5
Management of Epstein-Barr virus-related post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation.异基因造血干细胞移植后爱泼斯坦-巴尔病毒相关移植后淋巴增殖性疾病的管理
Ther Adv Hematol. 2020 Apr 28;11:2040620720910964. doi: 10.1177/2040620720910964. eCollection 2020.
6
Post-transplantation lymphoproliferative disorders: Current concepts and future therapeutic approaches.移植后淋巴细胞增生性疾病：当前概念与未来治疗方法
World J Transplant. 2020 Feb 28;10(2):29-46. doi: 10.5500/wjt.v10.i2.29.
7
Epstein-Barr viral load monitoring for diagnosing post-transplant lymphoproliferative disorder in pediatric liver transplant recipients.监测 Epstein-Barr 病毒载量以诊断儿童肝移植受者移植后淋巴增殖性疾病。
Pediatr Transplant. 2020 Jun;24(4):e13666. doi: 10.1111/petr.13666. Epub 2020 Feb 17.
8
Diagnostic Performance of F-FDG PET or PET/CT for Detection of Post-Transplant Lymphoproliferative Disorder: A Systematic Review and a Bivariate Meta-Analysis.F-FDG PET或PET/CT检测移植后淋巴增殖性疾病的诊断性能：一项系统评价和双变量Meta分析
Diagnostics (Basel). 2020 Feb 12;10(2):101. doi: 10.3390/diagnostics10020101.
9
Diagnostic performance of FDG-PET/CT of post-transplant lymphoproliferative disorder and factors affecting diagnostic yield.移植后淋巴组织增生性疾病的 FDG-PET/CT 诊断性能及影响诊断产量的因素。
Eur J Nucl Med Mol Imaging. 2020 Mar;47(3):529-536. doi: 10.1007/s00259-019-04481-7. Epub 2019 Aug 24.
10
Post-Transplant Lymphoproliferative Diseases in Pediatric Kidney Allograft Recipients with Epstein-Barr Virus Viremia.儿童肾移植受者伴 EBV 血症的移植后淋巴增殖性疾病。
J Korean Med Sci. 2019 Aug 5;34(30):e203. doi: 10.3346/jkms.2019.34.e203.

肾移植后移植后淋巴增殖性疾病的F-FDG PET/CT成像：三例临床病例

F-FDG PET/CT imaging of posttransplant lymphoproliferative disorder following renal transplantation: Three clinical cases.

作者信息

Pan Bo, Zhu Xingxing

机构信息

Division of PET/CT, Department of Nuclear Medicine, The First Affiliated Hospital of USTC, Hefei, 230001, China.

出版信息

Heliyon. 2023 Mar 22;9(4):e14746. doi: 10.1016/j.heliyon.2023.e14746. eCollection 2023 Apr.

DOI:10.1016/j.heliyon.2023.e14746
PMID:37012908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10066522/
Abstract

Posttransplant lymphoproliferative disorder (PTLD) is a serious complication of kidney transplantation, and whole-body F- FDG PET/CT imaging plays a key role in patients with PTLD. This article reports three cases of F-FDG PET/CT manifestations of gastric, prostate, and pulmonary lymphomas after kidney transplantation, all of which showed local lesions without involvement of adjacent or distant lymph nodes and lymphoid node organs. All patients were treated with a reduced dose of R-CHOP and were generally in a good condition after discharge. Early diagnosis and reasonable treatment are key factors in achieving a better prognosis in patients with PTLD, and whole-body F-FDG PET/CT imaging plays an important role in the diagnosis and monitoring of PTLD.

摘要

移植后淋巴细胞增生性疾病（PTLD）是肾移植的一种严重并发症，全身F-FDG PET/CT成像在PTLD患者中起着关键作用。本文报道了3例肾移植后胃、前列腺和肺淋巴瘤的F-FDG PET/CT表现，所有病例均显示局部病变，未累及相邻或远处淋巴结及淋巴器官。所有患者均接受了减量的R-CHOP治疗，出院后一般情况良好。早期诊断和合理治疗是PTLD患者获得较好预后的关键因素，全身F-FDG PET/CT成像在PTLD的诊断和监测中发挥着重要作用。