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在林奇综合征背景下,十二指肠纤维化酷似肿瘤性梗阻性肝病。

Duodenal Fibrosis Mimicking Neoplastic Obstructive Hepatopathy in the Setting of Lynch Syndrome.

作者信息

Hernandez Oscar L, Hussain Marwa, Suarez Zoilo K, Nagi Talwinder, Zahra Touqir

机构信息

Internal Medicine, Florida Atlantic University, Boca Raton, USA.

Medical School, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.

出版信息

Cureus. 2023 Mar 2;15(3):e35679. doi: 10.7759/cureus.35679. eCollection 2023 Mar.

Abstract

Intestinal fibrosis is a rare complication of chronic inflammation resulting from various etiologies, including surgery, abdominal radiation, and inflammatory bowel disease. Consequences of intestinal fibrosis include intestinal dysmotility, malabsorption, and obstruction. Patients with Lynch syndrome are predisposed to developing intestinal adenocarcinoma including in the small intestines which typically require intra-abdominal procedures that expose them to fibrogenic triggers. Here, we present a rare case of duodenal fibrosis involving the sphincter of Oddi leading to malabsorption and gastrointestinal symptoms in a patient with Lynch syndrome requiring advanced endoscopy interventions.

摘要

肠道纤维化是由多种病因引起的慢性炎症的罕见并发症,这些病因包括手术、腹部放疗和炎症性肠病。肠道纤维化的后果包括肠道运动障碍、吸收不良和梗阻。林奇综合征患者易患肠道腺癌,包括小肠腺癌,而小肠腺癌通常需要进行腹部手术,这会使他们暴露于促纤维化触发因素中。在此,我们报告一例罕见的十二指肠纤维化病例,该病例累及Oddi括约肌,导致一名林奇综合征患者出现吸收不良和胃肠道症状,需要进行高级内镜干预。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef8/10066623/63caf199fa63/cureus-0015-00000035679-i01.jpg

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