Ministry of Education Key Laboratory of Molecular and Cellular Biology; Hebei Research Center of the Basic Discipline of Cell Biology, Hebei Province Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, Hebei, China.
Cell Death Dis. 2023 Sep 22;14(9):628. doi: 10.1038/s41419-023-06144-w.
Kidney diseases remain one of the leading causes of human death and have placed a heavy burden on the medical system. Regulated cell death contributes to the pathology of a plethora of renal diseases. Recently, with in-depth studies into kidney diseases and cell death, a new iron-dependent cell death modality, known as ferroptosis, has been identified and has attracted considerable attention among researchers in the pathogenesis of kidney diseases and therapeutics to treat them. The majority of studies suggest that ferroptosis plays an important role in the pathologies of multiple kidney diseases, such as acute kidney injury (AKI), chronic kidney disease, and renal cell carcinoma. In this review, we summarize recently identified regulatory molecular mechanisms of ferroptosis, discuss ferroptosis pathways and mechanisms of action in various kidney diseases, and describe the protective effect of ferroptosis inhibitors against kidney diseases, especially AKI. By summarizing the prominent roles of ferroptosis in different kidney diseases and the progress made in studying ferroptosis, we provide new directions and strategies for future research on kidney diseases. In summary, ferroptotic factors are potential targets for therapeutic intervention to alleviate different kidney diseases, and targeting them may lead to new treatments for patients with kidney diseases.
肾脏疾病仍然是导致人类死亡的主要原因之一，给医疗系统带来了沉重的负担。受调控的细胞死亡是多种肾脏疾病发病机制的关键因素。最近，随着对肾脏疾病和细胞死亡的深入研究，一种新的铁依赖性细胞死亡方式——铁死亡，已经被确定，并在肾脏疾病发病机制和治疗研究中引起了广泛关注。大多数研究表明，铁死亡在多种肾脏疾病的病理中发挥着重要作用，如急性肾损伤（AKI）、慢性肾脏病和肾细胞癌。在本综述中，我们总结了铁死亡最近发现的调控分子机制，讨论了铁死亡途径和在各种肾脏疾病中的作用机制，并描述了铁死亡抑制剂对肾脏疾病，尤其是 AKI 的保护作用。通过总结铁死亡在不同肾脏疾病中的突出作用和在铁死亡研究方面取得的进展，为肾脏疾病的未来研究提供了新的方向和策略。总之，铁死亡相关因素可能是治疗干预以减轻不同肾脏疾病的潜在靶点，针对这些靶点可能为肾脏疾病患者带来新的治疗方法。
