Wang Ping, Liao Guihua, Wu Xi, Yu Rentao, Ma Jun
Department of Geriatrics, The General Hospital of Western Theater Command, Chengdu, Sichuan, P.R. China.
Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China.
Clin Exp Hypertens. 2023 Dec 31;45(1):2197568. doi: 10.1080/10641963.2023.2197568.
Brachial-ankle pulse wave velocity (baPWV) is an important clinical indicator of aortic stiffness and a risk predictor of cardiovascular disease and associated with obesity. However, whether body mass index (BMI) is associated with baPWV remains controversial. In our study, body fat-related indicators, including BMI, body fat rate (BFR), body fat volume (BFV), waist circumference (WC) were examined from healthy volunteers. We investigated the correlation of baPWV with these indicators and also assessed whether baPWV has the potential to predict these indicators.
A total of 429 healthy participants were enrolled in this study. Body fat indices, blood pressures, baPWV and blood metabolic indices were measured and recorded. The association of baPWV and indices reflecting body fat and blood pressure, as well as mediation effect were analyzed.
Three different types of baPWV values were significantly correlated. Mean level of baPWV was an independent risk factor for WC, BMI, BFR, and BFV (exp(β) = 1.011, 1.004, 1.010 and 1.009, respectively, < .001 for all) but not BMR. As for mediation effects, baPWV positively influenced WC (Total effect = 0.011, < .001), BMI (Total effect = 0.004, < .001) and BFV (Total effect = 0.009, < .001) in indirect way mediated by SBP and DBP, while baPWV influenced BFR in both direct (Effect = 0.004, = .018) and indirect way.
Levels of baPWV correlated with obesity and is an independent risk factor for WC, BMI, BFR and BFV. Besides, baPWV positively associated with WC, BMI and BFV mainly in indirect way mediated by SBP and DBP, and baPWV associated with BFR in both direct and indirect way.
肱踝脉搏波速度（baPWV）是主动脉僵硬度的一项重要临床指标，也是心血管疾病的风险预测指标，且与肥胖相关。然而，体重指数（BMI）是否与baPWV相关仍存在争议。在我们的研究中，对健康志愿者的包括BMI、体脂率（BFR）、体脂量（BFV）、腰围（WC）等体脂相关指标进行了检测。我们研究了baPWV与这些指标的相关性，并评估了baPWV预测这些指标的潜力。
本研究共纳入429名健康参与者。测量并记录体脂指数血压、baPWV和血液代谢指标。分析baPWV与反映体脂和血压的指标之间的关联以及中介效应。
三种不同类型的baPWV值显著相关。baPWV的平均水平是WC、BMI、BFR和BFV的独立危险因素（β值分别为1.011、1.004、1.010和1.009，均P<0.001），但与基础代谢率（BMR）无关。至于中介效应，baPWV通过收缩压（SBP）和舒张压（DBP）间接正向影响WC（总效应=0.011，P<0.001）、BMI（总效应=0.004，P<0.001）和BFV（总效应=0.009，P<0.001），而baPWV对BFR既有直接影响（效应=0.004，P=0.018）也有间接影响。
baPWV水平与肥胖相关，是WC、BMI、BFR和BFV的独立危险因素。此外，baPWV与WC、BMI和BFV的正相关主要通过SBP和DBP间接介导，而baPWV与BFR的关联既有直接方式也有间接方式。
