National Key Laboratory of Green Pesticide; State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou 510642, China.
J Agric Food Chem. 2023 Apr 12;71(14):5576-5584. doi: 10.1021/acs.jafc.3c00657. Epub 2023 Apr 4.
Applications of supramolecular materials in plant protection have attracted significant interest in recent years. To develop a feasible method to improve the efficacy and reduce the usage of chemical pesticides, the effect of calix[4]arene (C4A) inclusion on enhancing the insecticidal activity of commercial insecticides was investigated. Results showed that all three tested insecticides (chlorfenapyr, indoxacarb, and abamectin) with distinct molecular sizes and modes of action were able to form stable 1:1 host-guest complexes with C4A through simple preparation steps. The insecticidal activities of the complexes against were effectively enhanced compared to the guest molecule, with the synergism ratio being up to 3.05 (for indoxacarb). An obvious correlation was found between the enhanced insecticidal activity and the high binding affinity between insecticide and C4A, while the improvement in water solubility may not be a determining factor. The work would provide hints for the further development of functional supramolecular hosts as synergists in pesticide formulations.
近年来，超分子材料在植物保护中的应用引起了人们的极大关注。为了开发一种可行的方法来提高功效并减少化学农药的使用，研究了杯[4]芳烃（C4A）包合对增强商业杀虫剂杀虫活性的影响。结果表明，通过简单的制备步骤，三种不同分子大小和作用模式的测试杀虫剂（氯氟氰菊酯、茚虫威和阿维菌素）均能与 C4A 形成稳定的 1:1 主客体配合物。与客体分子相比，复合物对 的杀虫活性得到有效增强，增效比值高达 3.05（茚虫威）。杀虫活性的增强与杀虫剂与 C4A 之间的高结合亲和力之间存在明显的相关性，而提高水溶性可能不是一个决定因素。这项工作为进一步开发功能性超分子主体作为农药制剂中的增效剂提供了启示。
