Kunkel Gregory, Patel Hiren, Kaldany Alain, Allu Sai, Elsamra Sammy, Cancian Madeline
Department of Urology, UMass Chan: University of Massachusetts Medical School, Worcester, MA, USA.
Division of Urology, Rutgers University Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
World J Urol. 2023 May;41(5):1459-1468. doi: 10.1007/s00345-023-04378-z. Epub 2023 Apr 4.
Radiation is a common treatment modality for pelvic malignancies. While it can be effective at cancer control, downstream effects can manifest months to years after treatment, leaving patients with significant morbidity. Within urology, a particularly difficult post-radiation consequence is urinary tract stricture, either of the urethra, bladder neck, or ureter. In this review, we will discuss the mechanism of radiation damage and treatment options for these potentially devastating urinary sequelae.
放射治疗是盆腔恶性肿瘤的常见治疗方式。虽然它在控制癌症方面可能有效，但治疗后的下游效应可能在数月至数年后显现，给患者带来严重的发病率。在泌尿外科领域，一个特别棘手的放疗后后果是尿路狭窄，可发生于尿道、膀胱颈或输尿管。在本综述中，我们将讨论辐射损伤的机制以及针对这些可能具有毁灭性的泌尿系统后遗症的治疗选择。
