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[支架在尿道狭窄治疗中的应用]

[Stents in therapy of urethral strictures].

作者信息

Milroy E

机构信息

Institute of Urology, Middlesex Hospital, London, UK.

出版信息

Urologe A. 1998 Jan;37(1):51-5. doi: 10.1007/s001200050148.

Abstract

The human urethra seems remarkably tolerant of foreign material within its lumen. Providing that a stricture has been adequately cut by means of urethrotomy, or dilated with bougies, the majority of urethras will tolerate both permanent and temporary stents with few problems. Temporary stents have the obvious advantage over permanent stents that no foreign material is left in the urethra but before these can be recommended it is essential that more clinical experience is gained and that long term results up to ten years after removal of the stent are published. Great care is also needed in the use of any sort of permanent device, either the Urolume stent, or varieties of the Strecker such as the Memotherm device. These should not be used in children and should be probably be avoided in young adults. The majority of strictures in this age group are in any case treated more easily by single stage urethroplasty procedures. The use of permanent epithelial covering stents should be limited to the bulbo-membranous urethra, with the possible exception of carefully selected sphincters strictures used in combination with an artificial urinary sphincter. Better results will be obtained by using these stents in strictures with a short history before multiple urethrotomies and dilatations have been carried out and before extensive urethral and periurethral fibrosis has occurred. This means that urethral rupture strictures are unsuitable, and in any case these are simple to deal with be means of stricture excision and primary end to end anastomosis of the urethra particularly when the stricture is in the bulbar urethra. Care must also be taken in using these devices in post-urethroplasty strictures if extensive periurethral fibrosis exists, although it has to be admitted that these stents may be very successful in some of these patients. The difficulty at the present time is our inability to define exactly which traumatic stricture or post-urethroplasty stricture will succeed and which will fail. Metal urethral stents should not be used for the first treatment of a urethral stricture. Depending on the aetiology, the site and the length of the stricture there is always a 40-50% chance that the stricture may be cured by means of a simple urethrotomy or dilatation and this should always be tried at least once before resorting to urethral stenting. There is no doubt that permanent urethral stents have an important role to play in the treatment of recurrent urethral strictures. Careful patient selection is essential in order to achieve the best results and we need more long term results before the final role of these devices in the treatment of urethral strictures can be determined. Temporary stenting of the urethra with non-epithelial covering stents is a simpler and safer treatment but at this point in time we cannot be sure how effective this treatment is and for which patients it is most successful. Long term results must be awaited before the place of these temporary devices can be defined.

摘要

人类尿道似乎对其管腔内的异物具有显著的耐受性。只要通过尿道切开术充分切开狭窄部位,或用探条进行扩张,大多数尿道都能耐受永久性和临时性支架,且问题较少。临时性支架相对于永久性支架具有明显优势,即不会在尿道内留下异物,但在推荐使用之前,必须积累更多临床经验,并公布支架取出后长达十年的长期结果。在使用任何类型的永久性装置时,无论是Urolume支架还是Strecker的各种变体,如Memotherm装置,都需要格外小心。这些装置不应在儿童中使用,并且在年轻成年人中可能也应避免使用。在这个年龄组中,大多数狭窄情况无论如何通过一期尿道成形术都更容易治疗。永久性上皮覆盖支架的使用应限于球部-膜部尿道,精心挑选的括约肌狭窄与人工尿道括约肌联合使用时可能是个例外。在进行多次尿道切开术和扩张之前,且在广泛的尿道和尿道周围纤维化发生之前,对病史较短的狭窄使用这些支架会获得更好的效果。这意味着尿道破裂性狭窄不适合使用,而且无论如何,这些狭窄通过狭窄切除和尿道端端吻合术很容易处理,特别是当狭窄位于球部尿道时。如果存在广泛的尿道周围纤维化,在尿道成形术后狭窄中使用这些装置时也必须小心,尽管不得不承认这些支架在某些此类患者中可能非常成功。目前的困难在于我们无法确切界定哪些创伤性狭窄或尿道成形术后狭窄会成功,哪些会失败。金属尿道支架不应作为尿道狭窄的首次治疗方法。根据病因、狭窄部位和长度,总有40%至50%的机会通过简单的尿道切开术或扩张治愈狭窄,在诉诸尿道支架置入之前,应至少尝试一次这种方法。毫无疑问,永久性尿道支架在复发性尿道狭窄的治疗中具有重要作用。为了取得最佳效果,仔细选择患者至关重要,在确定这些装置在尿道狭窄治疗中的最终作用之前,我们需要更多的长期结果。用非上皮覆盖支架对尿道进行临时性支架置入是一种更简单、更安全的治疗方法,但目前我们无法确定这种治疗的效果如何,以及对哪些患者最成功。在确定这些临时性装置的地位之前,必须等待长期结果。

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