肠病毒与活减毒轮状病毒疫苗病毒在健康澳大利亚出生队列中的干扰作用。
Interference Between Enteric Viruses and Live-Attenuated Rotavirus Vaccine Virus in a Healthy Australian Birth Cohort.
机构信息
School of Medicine and Dentistry, and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia.
Departments of Infectious Diseases and Paediatrics, Gold Coast Health, Gold Coast, Australia.
出版信息
J Infect Dis. 2023 Oct 3;228(7):851-856. doi: 10.1093/infdis/jiad094.
BACKGROUND
Rotavirus vaccines have reduced effectiveness in high-mortality settings. Interference between enteric viruses and live-attenuated oral vaccine strains may be a factor.
METHODS
In a birth cohort of healthy Australian infants, parents collected weekly stool samples. Three hundred eighty-one paired swabs collected within 10-days of RotaTeq vaccination from 140 infants were tested for 10 enteric viruses and RotaTeq strains.
RESULTS
Collectively, both ribonucleic acid and deoxyribonucleic acid viruses were negatively associated with RotaTeq shedding (adjusted odds ratio = 0.29, 95% confidence interval = 0.14-0.58 and adjusted odds ratio = 0.30, 95% confidence interval = 0.11-0.78, respectively).
CONCLUSIONS
Enteric viruses may interfere with RotaTeq replication in the gut and thus RotaTeq stool shedding.
背景
轮状病毒疫苗在高死亡率环境中的效果降低。肠道病毒与减毒活口服疫苗株之间的干扰可能是一个因素。
方法
在一个健康的澳大利亚婴儿队列中，父母每周收集粪便样本。从 140 名婴儿中，有 140 名在 Rotateq 疫苗接种后 10 天内采集了 381 对棉签，检测了 10 种肠道病毒和 Rotateq 株。
结果
总的来说，核糖核酸和脱氧核糖核酸病毒与 Rotateq 脱落呈负相关（调整后的优势比=0.29，95%置信区间=0.14-0.58 和调整后的优势比=0.30，95%置信区间=0.11-0.78）。
结论
肠道病毒可能干扰 Rotateq 在肠道中的复制，从而影响 Rotateq 的粪便脱落。
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