Wesson Jane P, O'Dea Mark A, Hyndman Timothy H
Murdoch University, 90 South Street, Murdoch, Western Australia 6150, Australia.
Present address: Harry Butler Institute, 90 South Street, Murdoch, Western Australia 6150, Australia.
J Gen Virol. 2023 Apr;104(4). doi: 10.1099/jgv.0.001832.
Despite recent advances in molecular techniques, infection studies remain an important tool for biosecurity, veterinary and conservation medicines. Experimental infection studies are performed for many reasons: to investigate causal links between pathogens and disease, to study host species susceptibility, to study immune response to inoculation, to investigate pathogen transmission and to investigate methods for infection control. Experimental infection studies using viruses in reptiles have been conducted sporadically since at least the 1930s and this continues to be a fertile area of research. This review catalogues previously published research in the field. The key parameters of each study are tabulated, providing a summary of more than 100 experiments linked to their original publications. Common themes and trends within the data are discussed.
尽管分子技术最近取得了进展，但感染研究仍然是生物安全、兽医学和保护医学的重要工具。进行实验性感染研究有多种原因：调查病原体与疾病之间的因果关系、研究宿主物种的易感性、研究对接种的免疫反应、调查病原体传播以及研究感染控制方法。至少从20世纪30年代以来，就偶尔开展了使用病毒对爬行动物进行的实验性感染研究，并且这仍然是一个富有成果的研究领域。本综述对该领域以前发表的研究进行了编目。列出了每项研究的关键参数，总结了与原始出版物相关的100多项实验。讨论了数据中的共同主题和趋势。
