Chaudhry A P, Cutler L S, Yamane G M, Satchidanand S, Labay G, Sunderraj M
J Pathol. 1986 Mar;148(3):239-50. doi: 10.1002/path.1711480308.
This investigation deals with the histogenesis of the so-called 'epimyoepithelial islands' in Mikulicz's disease of the major salivary glands and is based on light and electron microscopic study in six patients. The 'epimyoepithelial islands' represent collapsed acini prior to their complete involution and disappearance, the intraductal cellular proliferation, stratification and differentiation into luminal and peripheral myoepithelial cells with partial and complete obliteration of their lumina and finally, cord-like proliferation and formation of nests of residual pluripotential cells showing squamous metaplasia and occasional myoepithelial cell differentiation. A pink, homogeneous and hyaline material on light microscopic examination is multilayered and extracellular and is in close association with the basal lamina when viewed with electron microscope.
本研究探讨了大唾液腺米库利奇病中所谓“肌上皮岛”的组织发生，基于对6例患者的光镜和电镜研究。“肌上皮岛”代表在完全退化和消失之前塌陷的腺泡、导管内细胞增殖、分层并分化为管腔和外周肌上皮细胞，管腔部分或完全闭塞，最后是残余多能细胞呈条索状增殖并形成巢，表现为鳞状化生并偶见肌上皮细胞分化。光镜检查时，一种粉红色、均质且透明的物质呈多层且位于细胞外，电镜观察时与基膜紧密相连。
