Chaudhry A P, Cutler L S, Leifer C, Satchidanand S, Labay G, Yamane G
J Pathol. 1986 Apr;148(4):307-20. doi: 10.1002/path.1711480407.
This study describes the light microscopic, histochemical and electron-microscopic findings of 10 acinic cell carcinomas from the major and minor salivary glands. Ultrastructurally, four cell types were identified: secretory acinar cells, intercalated duct-like cells, pluripotential reserve/stem cells and myoepithelial cells. This cellular composition suggests that the tumours are derived from neoplastic proliferation, cytodifferentiation and functional maturation of pluripotential reserve/stem cells which normally reside at the acinar-intercalated duct junctions and/or in the intercalated ducts proper of adult salivary glands. This study further supports the concept that different salivary gland tumours recapitulate various developmental stages in the normal embryogenesis of the salivary glands.
本研究描述了10例来自大、小唾液腺的腺泡细胞癌的光镜、组织化学和电镜检查结果。在超微结构上，鉴定出四种细胞类型：分泌性腺泡细胞、闰管样细胞、多能储备/干细胞和肌上皮细胞。这种细胞组成提示肿瘤来源于多能储备/干细胞的肿瘤性增殖、细胞分化和功能成熟，这些干细胞通常位于成年唾液腺的腺泡-闰管连接处和/或闰管内。本研究进一步支持了不同唾液腺肿瘤重现唾液腺正常胚胎发育中各个发育阶段的概念。
