Ophthalmology, Private Erzincan Neon Hospital, Erzincan, Turkey.
Ophthalmology, Duzce University Medical School, Duzce, Turkey.
Klin Monbl Augenheilkd. 2023 Aug;240(8):997-1003. doi: 10.1055/a-2040-4144. Epub 2023 Apr 4.
This study aimed to examine the long-term changes in anterior chamber depth (ACD), central corneal thickness (CCT), axial length (AxL), peripapillary retinal nerve fibre layer thickness (RNFLT), peripapillary ganglion cell layer - inner plexiform layer (GCL-IPL) thickness, and peripapillary choroidal thickness (ChT) after rhGH replacement treatment in paediatric patients with IGHD, compared to healthy controls.
Twenty-two children with IGHD including 12 girls and 10 boys were enrolled in the study group, and 30 (16 girls, 14 boys) healthy children composed the control group. A detailed ophthalmological examination was performed for each participant. ACD, CCT, AxL, peripapillary RNFLT, GCL-IPL thickness and ChT measurements were performed before the rhGH replacement treatment and in the 12th month of the post-treatment period, as well as the corresponding visits in the control group. AxL ultrasound pachymetry (CCT), peripapillary RNFL thickness, peripapillary RNFLT, GCL-IPL thickness, and peripapillary ChT parameters were measured by spectral-domain optical coherence tomography.
The mean age of the groups were similar (p = 0.143). 12-month CCT, ACD, and AxL measurements of the study group showed significantly higher results than the pre-treatment measurements (p = 0.005, p = 0.024, and p = 0.002, respectively). Similarly, the mean RNFLT and ChT measurements of the study group obtained from all sectors were significantly higher in the 12th-month visit (p < 0.001 for both) other than the RNFLT, and GCL-IPL thickness measurements (p > 0.05 for all). However, all these parameters were similar at pre- and post-treatment visits in the control group (p > 0.05 for all). The mean pre-treatment values of all these parameters were significantly lower in the study group compared to the control group (p < 0.05 for all), other than the RNFLT, GCL-IPL thickness measurements (p > 0.05 for all), while the mean post-treatment values of all these parameters in both groups were similar at month 12 (p > 0.05 for all).
GH replacement treatment in childhood may play an important role in the development of the neural retina and can be effective on the anterior segment, RNFLT and ChT measurements.
本研究旨在观察生长激素（rhGH）替代治疗对儿童生长激素缺乏症（IGHD）患者前房深度（ACD）、中央角膜厚度（CCT）、眼轴（AxL）、视盘周围视网膜神经纤维层厚度（RNFLT）、视盘周围节细胞层-内丛状层（GCL-IPL）厚度和视盘周围脉络膜厚度（ChT）的长期变化，并与健康对照组进行比较。
研究组纳入 22 名 IGHD 患儿，包括 12 名女孩和 10 名男孩，对照组纳入 30 名（16 名女孩，14 名男孩）健康儿童。对每位参与者进行详细的眼科检查。在 rhGH 替代治疗前和治疗后 12 个月以及对照组的相应访视中，分别对 ACD、CCT、AxL、视盘周围 RNFLT、GCL-IPL 厚度和 ChT 进行测量。AxL 超声测厚（CCT）、视盘周围 RNFL 厚度、视盘周围 RNFLT、GCL-IPL 厚度和视盘周围 ChT 参数采用频域光学相干断层扫描（OCT）进行测量。
两组的平均年龄相似（p=0.143）。治疗组的 12 个月 CCT、ACD 和 AxL 测量结果明显高于治疗前（p=0.005、p=0.024 和 p=0.002）。同样，研究组所有象限的平均 RNFLT 和 ChT 测量值在第 12 个月时也明显升高（均 p<0.001），但 RNFLT 和 GCL-IPL 厚度测量值除外（均 p>0.05）。然而，对照组在治疗前后的所有参数均相似（均 p>0.05）。研究组所有这些参数的治疗前平均值均明显低于对照组（均 p<0.05），但 RNFLT 和 GCL-IPL 厚度测量值除外（均 p>0.05），而两组在第 12 个月时所有这些参数的治疗后平均值相似（均 p>0.05）。
儿童时期的 GH 替代治疗可能在神经视网膜发育中发挥重要作用，并且对前节、RNFLT 和 ChT 测量值有效。
