IEEE Trans Biomed Eng. 2023 Jun;70(6):1902-1910. doi: 10.1109/TBME.2022.3232038. Epub 2023 May 19.
Tissue electroporation is the basis of several therapies. Electroporation is performed by briefly exposing tissues to high electric fields. It is generally accepted that electroporation is effective where an electric field magnitude threshold is overreached. However, it is difficult to preoperatively estimate the field distribution because it is highly dependent on anatomy and treatment parameters.
We developed PIRET, a platform to predict the treatment volume in electroporation-based therapies.
The platform seamlessly integrates tools to build patient-specific models where the electric field is simulated to predict the treatment volume. Patient anatomy is segmented from medical images and 3D reconstruction aids in placing the electrodes and setting up treatment parameters.
Four canine patients that had been treated with high-frequency irreversible electroporation were retrospectively planned with PIRET and with a workflow commonly used in previous studies, which uses different general-purpose segmentation (3D Slicer) and modeling software (3Matic and COMSOL Multiphysics). PIRET outperformed the other workflow by 65 minutes (× 1.7 faster), thanks to the improved user experience during treatment setup and model building. Both approaches computed similarly accurate electric field distributions, with average Dice scores higher than 0.93.
A platform which integrates all the required tools for electroporation treatment planning is presented. Treatment plan can be performed rapidly with minimal user interaction in a stand-alone platform.
This platform is, to the best of our knowledge, the most complete software for treatment planning of irreversible electroporation. It can potentially be used for other electroporation applications.
组织电穿孔是几种治疗方法的基础。电穿孔是通过短暂地将组织暴露在强电场中来完成的。通常认为，当电场强度超过阈值时，电穿孔是有效的。然而，由于它高度依赖于解剖结构和治疗参数，因此很难在术前估计场分布。
我们开发了 PIRET，这是一种用于预测基于电穿孔的治疗体积的平台。
该平台无缝集成了用于构建患者特定模型的工具，其中电场被模拟以预测治疗体积。患者解剖结构从医学图像中分割出来，3D 重建有助于放置电极和设置治疗参数。
回顾性地对 4 只接受高频不可逆电穿孔治疗的犬进行了 PIRET 规划和先前研究中常用的工作流程规划，该工作流程使用不同的通用分割（3D Slicer）和建模软件（3Matic 和 COMSOL Multiphysics）。PIRET 比其他工作流程快 65 分钟（快 1.7 倍），这要归功于在治疗设置和模型构建过程中改进的用户体验。两种方法都计算出了类似的准确电场分布，平均 Dice 分数高于 0.93。
提出了一种集成了电穿孔治疗计划所需的所有工具的平台。该平台在独立平台上以最小的用户交互快速执行治疗计划。
据我们所知，该平台是不可逆电穿孔治疗计划最完整的软件。它可能用于其他电穿孔应用。
