Silva Pedro Henrique Alcântara da, Romão Lourena Guedes de Melo, Freitas Natércia Paula Alves de, Carvalho Thiago Ribeiro, Porto Maria Eduarda Mendes Pontes, Araujo Júnior Edward, Cavalcante Marcelo Borges
Reproductive Medicine Sector, CONCEPTUS, Fortaleza, CE, Brazil.
Ana Bezerra University Hospital - Federal University of Rio Grande do Norte (UFRN), Santa Cruz, RN, Brazil.
J Matern Fetal Neonatal Med. 2023 Dec;36(1):2197097. doi: 10.1080/14767058.2023.2197097.
A highly accurate serum marker for predicting viable pregnancy needs to be developed. Recent studies have demonstrated that kisspeptin is a potential biomarker for this purpose.
This systematic review evaluated the available data in the literature on the role of kisspeptin as a miscarriage biomarker. A literature search was conducted in the PubMed/Medline, Embase, Web of Science, and Scopus databases using the following keywords: (kisspeptin) AND (miscarriage OR pregnancy loss OR spontaneous abortion OR reproductive failure).
Seven case-control studies were selected for the systematic review. The included papers described the potential role of kisspeptin as a putative biomarker of pregnancy loss. Furthermore, two studies reported that changes in kisspeptin levels may be associated with unexplained infertility and low rates of embryo implantation in women undergoing assisted reproductive technology.
Kisspeptin might be used as a potential biomarker of pregnancy viability in the near future. However, studies with better evidence are needed to establish the applicability of kisspeptin as a diagnostic and prognostic tool.
需要开发一种用于预测存活妊娠的高度准确的血清标志物。最近的研究表明， kisspeptin是用于此目的的一种潜在生物标志物。
本系统评价评估了文献中关于kisspeptin作为流产生物标志物作用的现有数据。使用以下关键词在PubMed/Medline、Embase、Web of Science和Scopus数据库中进行文献检索：（kisspeptin） AND （流产 OR 妊娠丢失 OR 自然流产 OR 生殖失败）。
七项病例对照研究被选入本系统评价。纳入的论文描述了kisspeptin作为妊娠丢失假定生物标志物的潜在作用。此外，两项研究报告称，kisspeptin水平的变化可能与不明原因的不孕症以及接受辅助生殖技术的女性胚胎着床率低有关。
在不久的将来，kisspeptin可能用作妊娠存活的潜在生物标志物。然而，需要有更好证据的研究来确定kisspeptin作为诊断和预后工具的适用性。
