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膳食脂肪酸对人 THP-1 单核细胞促炎细胞因子分泌的影响存在差异。

Dietary fatty acids differentially affect secretion of pro-inflammatory cytokines in human THP-1 monocytes.

机构信息

Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, 81362, Taiwan.

Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, 1 Ta Hsueh Road, Tainan, 70101, Taiwan.

出版信息

Sci Rep. 2023 Apr 4;13(1):5511. doi: 10.1038/s41598-023-32710-5.

DOI:10.1038/s41598-023-32710-5
PMID:37016048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10073224/
Abstract

Monocytes are a major population of circulating immune cells that play a crucial role in producing pro-inflammatory cytokines in the body. The actions of monocytes are known to be influenced by the combinations and concentrations of certain fatty acids (FAs) in blood and dietary fats. However, systemic comparisons of the effects of FAs on cytokine secretion by monocytes have not be performed. In this study, we compared how six saturated FAs (SFAs), two monounsaturated FAs (MUFAs), and seven polyunsaturated FAs (PUFAs) modulate human THP-1 monocyte secretion of TNF, IL-1β, and IL-6 in the absence or presence of lipopolysaccharide. SFAs generally stimulated resting THP-1 cells to secrete pro-inflammatory cytokines, with stearic acid being the most potent species. In contrast, MUFAs and PUFAs inhibited lipopolysaccharide-induced secretion of pro-inflammatory cytokines. Interestingly, the inhibitory potentials of MUFAs and PUFAs followed U-shaped (TNF and IL-1β) or inverted U-shaped (IL-6) dose-response curves. Among the MUFAs and PUFAs that were analyzed, docosahexaenoic acid (C22:6 n-3) exhibited the largest number of double bonds and was found to be the most potent anti-inflammatory compound. Together, our findings reveal that the chemical compositions and concentrations of dietary FAs are key factors in the intricate regulation of monocyte-mediated inflammation.

摘要

单核细胞是循环免疫细胞的主要群体，在体内产生促炎细胞因子方面发挥着关键作用。单核细胞的作用已知受血液和膳食脂肪中某些脂肪酸 (FA) 的组合和浓度的影响。然而，尚未对 FA 对单核细胞细胞因子分泌的系统影响进行比较。在这项研究中，我们比较了六种饱和脂肪酸 (SFA)、两种单不饱和脂肪酸 (MUFA) 和七种多不饱和脂肪酸 (PUFA) 在有无脂多糖的情况下如何调节人 THP-1 单核细胞分泌 TNF、IL-1β 和 IL-6。SFA 通常会刺激静止的 THP-1 细胞分泌促炎细胞因子，硬脂酸是最有效的物质。相比之下，MUFA 和 PUFAs 抑制脂多糖诱导的促炎细胞因子分泌。有趣的是，MUFA 和 PUFAs 的抑制潜力遵循 U 形（TNF 和 IL-1β）或倒 U 形（IL-6）剂量反应曲线。在所分析的 MUFA 和 PUFAs 中，二十二碳六烯酸 (C22:6 n-3) 具有最多的双键，被发现是最有效的抗炎化合物。总之，我们的研究结果表明，膳食 FA 的化学成分和浓度是单核细胞介导的炎症复杂调节的关键因素。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f5e/10073224/2bfc00b3f6ce/41598_2023_32710_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f5e/10073224/badc7cf79e96/41598_2023_32710_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f5e/10073224/e46bf5b880e7/41598_2023_32710_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f5e/10073224/2abea993b0a4/41598_2023_32710_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f5e/10073224/c619a9807dbd/41598_2023_32710_Fig9_HTML.jpg

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