Department of Physiology and Pathophysiology, Jerry M. Wallace School of Osteopathic Medicine, Campbell University SOM, Buies Creek, NC, USA.
Department of Biology, College of Arts and Sciences, University of North Carolina, Greensboro, NC, USA.
Clin Exp Med. 2023 Nov;23(7):2941-2951. doi: 10.1007/s10238-023-01051-y. Epub 2023 Apr 4.
Metformin is among the most widely used antidiabetic drugs. Studies over the past few years have identified multiple novel molecular targets and pathways that metformin acts on to exert its beneficial effects in treating type 2 diabetes as well as other disorders involving dysregulated inflammation and redox homeostasis. In this mini-review, we discuss the latest cutting-edge research discoveries on novel molecular targets of metformin in glycemic control, cardiovascular protection, cancer intervention, anti-inflammation, antiaging, and weight control. Identification of these novel targets and pathways not only deepens our understanding of the molecular mechanisms by which metformin exerts diverse beneficial biological effects, but also provides opportunities for developing new mechanistically based drugs for human diseases.
二甲双胍是最广泛使用的抗糖尿病药物之一。在过去的几年中，多项研究已经确定了多种新型分子靶点和途径，二甲双胍通过这些靶点和途径发挥其在治疗 2 型糖尿病以及其他涉及失调的炎症和氧化还原平衡的疾病方面的有益作用。在这篇迷你综述中，我们讨论了二甲双胍在血糖控制、心血管保护、癌症干预、抗炎、抗衰老和体重控制方面的新型分子靶点的最新前沿研究发现。这些新型靶点和途径的鉴定不仅加深了我们对二甲双胍发挥多种有益生物学作用的分子机制的理解，也为开发针对人类疾病的新型基于机制的药物提供了机会。
