Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, 250100, P. R. China.
State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong, 266237, P. R. China.
Adv Healthc Mater. 2023 Sep;12(22):e2300249. doi: 10.1002/adhm.202300249. Epub 2023 Apr 25.
Nanovaccine-based immunotherapy can initiate strong immune responses and establish a long-term immune memory to prevent tumor invasion and recurrence. Herein, the assembly of redox-responsive antigen nanoparticles (NPs) conjugated with imidazoquinoline-based TLR7/8 agonists for lymph node-targeted immune activation is reported, which can potentiate tumor therapy and prevention. Antigen NPs are assembled via the templating of zeolitic imidazolate framework-8 NPs to cross-link ovalbumin with disulfide bonds, which enables the NPs with redox-responsiveness for improved antigen cross-presentation and dendritic cell activation. The formulated nanovaccines promote the lymphatic co-delivery of antigens and agonists, which can trigger immune responses of cytotoxic T lymphocytes and strong immunological memory. Notably, nanovaccines demonstrate their superiority for tumor prevention owing to the elicited robust antitumor immunity. The reported strategy provides a rational design of nanovaccines for enhanced cancer immunotherapy.
基于纳米疫苗的免疫疗法可以引发强烈的免疫反应，并建立长期的免疫记忆，以防止肿瘤的侵袭和复发。在此，报道了一种基于氧化还原响应性抗原纳米颗粒（NPs）与咪唑并喹啉类 TLR7/8 激动剂的组装，用于淋巴结靶向免疫激活，可增强肿瘤治疗和预防效果。抗原 NPs 通过沸石咪唑骨架-8 NPs 的模板组装，使卵清蛋白与二硫键交联，使 NPs 具有氧化还原响应性，从而改善抗原交叉呈递和树突状细胞激活。所构建的纳米疫苗促进了抗原和激动剂的淋巴共递，从而引发细胞毒性 T 淋巴细胞的免疫反应和强烈的免疫记忆。值得注意的是，纳米疫苗由于引发了强大的抗肿瘤免疫，因此在肿瘤预防方面表现出了优越性。所报道的策略为增强癌症免疫疗法的纳米疫苗设计提供了一种合理的方法。
