School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, P. R. China.
Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, Anhui, P. R. China.
Chem Soc Rev. 2023 Apr 24;52(8):2833-2865. doi: 10.1039/d2cs00586g.
Metallenes, atomically thin-layered materials composed of coordination-deficient metal atoms, have emerged as a new category of two-dimensional materials. Metallenes exhibit exciting properties with a fusion of atom economy, ultrathin structure, photonic properties, and catalytic activity, which make them intriguing for a wide range of applications in biomedicine. The development of biomedical applications of metallenes is in its infancy yet fast-growing. In this review, after a brief introduction of the definition, structures, properties, and classification of metallenes, we outline two common synthesis strategies and identify their shortcomings. Then, we comprehensively discuss the biological effects of metallenes, such as nano-biointeractions and signaling pathway regulation. We also highlight their recent advances in biomedical applications, including antitumor, biosensing, bioimaging, antibacterial, and anti-inflammation. Finally, we provide personal perspectives on remaining challenges and future opportunities for the biomedical applications of metallenes.
金属烯，由配位不饱和金属原子组成的原子层状材料，已成为二维材料的一个新类别。金属烯具有原子经济性、超薄结构、光子特性和催化活性的融合，这使得它们在生物医学领域的广泛应用中具有吸引力。金属烯的生物医学应用的发展虽然还处于起步阶段，但发展迅速。在简要介绍了金属烯的定义、结构、性质和分类之后，本文概述了两种常见的合成策略，并指出了它们的缺点。然后，我们全面讨论了金属烯的生物效应，如纳米生物相互作用和信号通路调节。我们还强调了它们在生物医学应用中的最新进展，包括抗肿瘤、生物传感、生物成像、抗菌和抗炎。最后，我们对金属烯在生物医学应用中仍然存在的挑战和未来的机遇提出了个人看法。
