Department of Molecular Diagnosis Center, The Sixth Affiliated Hospital of Guangzhou Medical University, Guangdong, China.
School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
Eur J Immunol. 2023 Jun;53(6):e2250268. doi: 10.1002/eji.202250268. Epub 2023 May 2.
The immune system of vertebrates includes innate immunity and adaptive immunity, and the network between them enables the host to fight against invasions of various pathogens. Recently, studies discovered that immune memory is one of the features of innate immunity, breaking the previous opinion that immune memory exists only in adaptive immunity. Immune memory supports innate immune cells to respond efficiently upon reinfection or restimulation. During the Plasmodium infection, the innate immune system is the first to be triggered, and innate immune cells are activated by components from Plasmodium or Plasmodium-infected red blood cells. Innate immune cells could be induced to develop memory after the activation and may play an important role in the subsequent infection of Plasmodium or other pathogens and stimulation. This review will discuss the recent findings relevant to trained immunity and Plasmodium infection, facilitating the understanding of the role of trained immunity in malaria and other diseases and the development of therapeutic strategies based on trained immunity.
脊椎动物的免疫系统包括先天免疫和适应性免疫，它们之间的网络使宿主能够对抗各种病原体的入侵。最近的研究发现，免疫记忆是先天免疫的特征之一，打破了先前认为免疫记忆仅存在于适应性免疫中的观点。免疫记忆支持先天免疫细胞在再次感染或再刺激时有效反应。在疟原虫感染期间，先天免疫系统首先被触发，先天免疫细胞被疟原虫或疟原虫感染的红细胞的成分激活。先天免疫细胞在激活后可被诱导产生记忆，并可能在随后的疟原虫或其他病原体感染和刺激中发挥重要作用。这篇综述将讨论与训练免疫和疟原虫感染相关的最新发现，有助于理解训练免疫在疟疾和其他疾病中的作用，并为基于训练免疫的治疗策略的发展提供信息。
