Department of Ophthalmology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, China.
Int Wound J. 2023 Dec;20(10):4422-4428. doi: 10.1111/iwj.14324. Epub 2023 Jul 24.
With the outbreak and pandemic of coronavirus disease-2019 (COVID-19), a huge number of people died of it. Apart from lung injuries, multiple organs have been confirmed to be impaired. In COVID-19 time, primary wound healing processes always prolong, however, its possible underlying mechanisms are still unclear. Therefore, to overcome this clinical problem, clarifying its underlying mechanisms clearly is necessary and urgently needed. In this review, we summarized that COVID-19 can prolong primary wound healing by inducing excessive inflammation and oxidative stress, disturbing immune system and haematological system, as well as influencing the functions and viability of epidermal stem cells (ESCs). Otherwise, we summarized that the strict control measures of blocking up COVID-19 pandemic can also have side effects on primary wound healing process.
随着 2019 冠状病毒病（COVID-19）的爆发和大流行，大量人因此病死亡。除了肺部损伤外，还证实多个器官受到损害。在 COVID-19 期间，初级伤口愈合过程总是延长，然而，其潜在的机制仍不清楚。因此，要克服这一临床问题，明确其潜在机制是必要和急需的。在这篇综述中，我们总结了 COVID-19 可以通过诱导过度炎症和氧化应激、扰乱免疫系统和血液系统以及影响表皮干细胞（ESCs）的功能和活力来延长初级伤口愈合。此外，我们还总结了严格控制 COVID-19 大流行的措施也可能对初级伤口愈合过程产生副作用。
