Gao Huihui, Zhou Ying, Chen Xue
School of Life Sciences, Shanghai University, Shanghai 200444, China.
School of Life Sciences, Shanghai University, Shanghai 200444, China; Department of Oncology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China.
Crit Rev Immunol. 2022;42(2):59-69. doi: 10.1615/CritRevImmunol.2023047234.
Regulatory T cells (Tregs), a fraction of CD4+ T cells with immunosuppressive characteristics, are strongly linked to a number of inflammatory and autoimmune disorders. Furthermore, it also contributes to the development of tumors. Tregs infiltrate into the tumor microenvironment (TME), dampen the anti-tumor immune reaction, and facilitate tumoral immune escape. Besides the well-known hemostatic roles, mounting evidence indicates that platelets may also function as immune cells and engage in cancer immune escape. In addition, substantial evidence shows that platelets or platelet-derived mediators can regulate the proliferation, differentiation, and functions of many immune cells. Platelets also play important roles in promoting tumor cell proliferation and helping tumor cells evade immune surveillance. Here we summarize the regulatory effects of platelets in Treg proliferation, differentiation and functions and highlight the potential synergistic roles of platelets and Tregs in tumor cell immune escape.
调节性T细胞（Tregs）是具有免疫抑制特性的CD4+ T细胞亚群，与多种炎症和自身免疫性疾病密切相关。此外，它还促进肿瘤的发展。Tregs浸润到肿瘤微环境（TME）中，抑制抗肿瘤免疫反应，并促进肿瘤免疫逃逸。除了众所周知的止血作用外，越来越多的证据表明血小板也可能作为免疫细胞发挥作用，并参与癌症免疫逃逸。此外，大量证据表明血小板或血小板衍生介质可以调节许多免疫细胞的增殖、分化和功能。血小板在促进肿瘤细胞增殖和帮助肿瘤细胞逃避免疫监视方面也发挥着重要作用。在这里，我们总结了血小板在Treg增殖、分化和功能方面的调节作用，并强调了血小板和Tregs在肿瘤细胞免疫逃逸中的潜在协同作用。
