Wang Haiping, Franco Fabien, Ho Ping-Chih
Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Vaud, Switzerland; Ludwig Lausanne Branch, Epalinges, Vaud, Switzerland.
Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Vaud, Switzerland; Ludwig Lausanne Branch, Epalinges, Vaud, Switzerland.
Trends Cancer. 2017 Aug;3(8):583-592. doi: 10.1016/j.trecan.2017.06.005. Epub 2017 Jul 14.
The promising outcomes observed in cancer immunotherapy are evidence that the immune system provides a powerful arsenal for the restriction of tumor outgrowth; however, the immunosuppressive tumor microenvironment (TME) is known to impair antitumor immunity and impede the efficacy of cancer immunotherapies. Regulatory T cells (Tregs), which prevent overt immune responses and autoimmunity, accumulate aberrantly in some types of tumor to suppress antitumor immunity and support the establishment of an immunosuppressive microenvironment. Ablation of Tregs has been shown to not only unleash antitumor immunity and interrupt formation of an immunosuppressive TME, but also lead to severe autoimmune disorders. Therefore, it is essential to develop approaches to specifically target intratumoral Tregs. Herein, we summarize the immunomodulatory functions of Tregs in the TME and discuss how metabolic regulation of Tregs can facilitate intratumoral Treg accumulation.
癌症免疫疗法中观察到的有前景的结果证明，免疫系统为限制肿瘤生长提供了强大的武器库；然而，众所周知，免疫抑制性肿瘤微环境（TME）会损害抗肿瘤免疫力并阻碍癌症免疫疗法的疗效。调节性T细胞（Tregs）可防止过度的免疫反应和自身免疫，在某些类型的肿瘤中异常积聚，以抑制抗肿瘤免疫力并支持免疫抑制性微环境的形成。已证明消除Tregs不仅能释放抗肿瘤免疫力并中断免疫抑制性TME的形成，还会导致严重的自身免疫性疾病。因此，开发特异性靶向肿瘤内Tregs的方法至关重要。在此，我们总结了Tregs在TME中的免疫调节功能，并讨论了Tregs的代谢调节如何促进肿瘤内Tregs的积聚。
