Inoue Emi, Hiroumi Shiori, Sato Sachina, Hayashi Misa, Konaka Hachiro, Tsuji Shigeyoshi, Higashiyama Mari
Department of Dermatology, Nippon Life Hospital, Osaka, Japan.
Department of Respiratory Medicine and Clinical Immunology, Nippon Life Hospital, Osaka, Japan.
J Dermatol. 2023 Aug;50(8):1076-1080. doi: 10.1111/1346-8138.16794. Epub 2023 Apr 5.
Pustulotic arthro-osteitis (PAO) is a rare chronic inflammatory arthropathy associated with palmoplantar pustulosis. The pathogenesis of PAO remains unclear. The most common musculoskeletal involvement in PAO is ossification of the sternoclavicular joints. A combination of parietal inflammation and hyperostosis-induced mechanical compression in this region is hypothesized to contribute to multiple venous thrombosis. Here, we present a 66-year-old man with PAO-associated multiple venous occlusion who was successfully treated with guselkumab. We also discuss its clinical manifestation and cause by reviewing the literature.
脓疱性关节骨炎（PAO）是一种与掌跖脓疱病相关的罕见慢性炎症性关节病。PAO的发病机制尚不清楚。PAO最常见的肌肉骨骼受累部位是胸锁关节骨化。据推测，该区域的壁层炎症和骨增生引起的机械压迫共同导致了多发性静脉血栓形成。在此，我们报告一名66岁患有PAO相关多发性静脉闭塞的男性患者，其接受古塞库单抗治疗成功。我们还通过回顾文献讨论了其临床表现及病因。
