4-芳酰基-1,3-二氢-2H-咪唑-2-酮：一类新型强心剂。2. 4-吡啶甲酰基取代基及相关化合物的作用。
4-Aroyl-1,3-dihydro-2H-imidazol-2-ones: a new class of cardiotonic agents. 2. Effect of 4-pyridoyl substituents and related compounds.
作者信息
Schnettler R A, Dage R C, Palopoli F P
出版信息
J Med Chem. 1986 May;29(5):860-2. doi: 10.1021/jm00155a043.
PMID:3701794
Abstract
A group of 4-pyridoyl-1,3-dihydro-2H-imidazol-2-ones was prepared and tested for inotropic activity in the anesthetized dog. Positive inotropic effects as well as increases in heart rate and decreases in blood pressure were noted for most of these compounds. One of the compounds (8) is currently undergoing clinical trials for the treatment of congestive heart failure.
摘要
制备了一组4-吡啶甲酰基-1,3-二氢-2H-咪唑-2-酮，并在麻醉犬身上测试了其正性肌力活性。大多数这些化合物都显示出正性肌力作用以及心率增加和血压降低的效果。其中一种化合物（8）目前正在进行治疗充血性心力衰竭的临床试验。
相似文献
1
4-Aroyl-1,3-dihydro-2H-imidazol-2-ones: a new class of cardiotonic agents. 2. Effect of 4-pyridoyl substituents and related compounds.4-芳酰基-1,3-二氢-2H-咪唑-2-酮：一类新型强心剂。2. 4-吡啶甲酰基取代基及相关化合物的作用。
J Med Chem. 1986 May;29(5):860-2. doi: 10.1021/jm00155a043.
2
4-Aroyl-1,3-dihydro-2H-imidazol-2-ones, a new class of cardiotonic agents.4-芳酰基-1,3-二氢-2H-咪唑-2-酮类，一类新型强心剂。
J Med Chem. 1982 Dec;25(12):1477-81. doi: 10.1021/jm00354a017.
3
Cardiotonic agents. 2. Synthesis and structure-activity relationships of 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones: a new class of positive inotropic agents.
J Med Chem. 1985 Oct;28(10):1405-13. doi: 10.1021/jm00148a006.
4
Cardiotonic agents. 5. 1,2-Dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-6-methyl-2-oxo-3- pyridinecarbonitriles and related compounds. Synthesis and inotropic activity.强心剂。5. 1,2 - 二氢 - 5 - [4 - (1H - 咪唑 - 1 - 基)苯基] - 6 - 甲基 - 2 - 氧代 - 3 - 吡啶甲腈及相关化合物。合成与变力活性。
J Med Chem. 1987 Jun;30(6):1023-9. doi: 10.1021/jm00389a011.
5
6
Imidazo[1,2-alpha]pyridines. II. Ozonolysis of imidazo[1,2-alpha]pyridines and synthesis of cardiotonic agents.咪唑并[1,2-α]吡啶。II. 咪唑并[1,2-α]吡啶的臭氧分解及强心剂的合成。
Chem Pharm Bull (Tokyo). 1992 Mar;40(3):666-74. doi: 10.1248/cpb.40.666.
7
Cardiotonic agents. 9. Synthesis and biological evaluation of a series of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3 (2H)-pyridazinones: a novel class of compounds with positive inotropic, antithrombotic, and vasodilatory activities for the treatment of congestive heart failure.强心剂。9. 一系列(E)-4,5-二氢-6-[2-[4-(1H-咪唑-1-基)苯基]乙烯基]-3(2H)-哒嗪酮的合成与生物学评价：一类用于治疗充血性心力衰竭的具有正性肌力、抗血栓形成和血管舒张活性的新型化合物。
J Med Chem. 1989 Feb;32(2):342-50. doi: 10.1021/jm00122a011.
8
Studies on cardiotonic agents. VI. Synthesis of novel 4,5-dihydro-3(2H)-pyridazinone derivatives carrying some benzoheterocycles at the 6-position.
Chem Pharm Bull (Tokyo). 1991 Feb;39(2):352-7. doi: 10.1248/cpb.39.352.
9
Characterization of the cardiovascular activities of a new cardiotonic agent, MDL 17043 (1,3-dihydro-4-methyl-5-[4-(methylthio)-benzoyl]-2H-imidazole-2-one).
J Cardiovasc Pharmacol. 1982 Sep-Oct;4(5):721-9. doi: 10.1097/00005344-198209000-00005.
10
In vivo cardiotonic activity of aryl- and pyridyl-substituted fused imidazoles.
Arzneimittelforschung. 1998 Mar;48(3):232-5.
Zotero 插件