Parton R
J Med Microbiol. 1986 May;21(3):265-70. doi: 10.1099/00222615-21-3-265.
Bordetella pertussis heat-labile toxin (HLT) was assayed by the haemorrhagic response produced by subcutaneous injection into weaned mice. Young mice, 3-5 weeks old of either sex, were highly responsive but they became resistant to HLT as they matured. Two anti-inflammatory agents, prednisolone and meclofenamate, inhibited the skin reactions in young mice. When given intraperitoneally, prednisolone was most inhibitory if it was injected just before, or at the same time as, HLT challenge. Prednisolone given 3 h after challenge, when the skin reactions had started to develop, did not significantly attenuate the final response. Both drugs were even more effective when mixed with the HLT challenge and injected subcutaneously. These findings are discussed in relation to the possible mechanism of action of HLT and to the reported beneficial effects of corticosteroids in the treatment of whooping cough.
通过对断奶小鼠皮下注射产生的出血反应来测定百日咳博德特氏菌不耐热毒素（HLT）。3至5周龄的雌雄幼鼠对HLT反应强烈，但随着它们成熟，会对HLT产生抗性。两种抗炎药泼尼松龙和甲氯芬那酸可抑制幼鼠的皮肤反应。腹腔注射时，泼尼松龙若在HLT攻击前或同时注射，抑制作用最强。在皮肤反应开始出现的攻击后3小时给予泼尼松龙，并不会显著减弱最终反应。两种药物与HLT攻击混合并皮下注射时效果更佳。结合HLT可能的作用机制以及皮质类固醇在治疗百日咳方面已报道的有益效果对这些发现进行了讨论。
