Parton R
J Med Microbiol. 1985 Jun;19(3):391-400. doi: 10.1099/00222615-19-3-391.
Prednisolone, given orally or intraperitoneally before challenge, protected mice against the lethal effect of a crude cell extract of Bordetella pertussis containing heat-labile toxin (HLT) as the major toxic component. Prednisolone did not diminish the lethal toxicity of heated B. pertussis cell suspensions containing pertussis toxin and endotoxin but devoid of HLT. This suggests that the protective effect of the steroid was directed against the HLT. When live bacteria were injected intraperitoneally, prednisolone showed a protective effect against the initial toxaemia. By day 7, however, the protection was no longer evident and the steroid promoted the survival of the organisms within the peritoneal cavity. These findings are discussed in the light of reports of the beneficial effects of corticosteroids in the treatment of whooping cough and in relation to a possible role for HLT in the pathogenesis of the disease.
在攻击前口服或腹腔注射泼尼松龙，可保护小鼠免受含有热不稳定毒素（HLT）作为主要毒性成分的百日咳博德特氏菌粗细胞提取物的致死作用。泼尼松龙不会降低含有百日咳毒素和内毒素但不含HLT的加热百日咳博德特氏菌细胞悬液的致死毒性。这表明类固醇的保护作用是针对HLT的。当腹腔注射活细菌时，泼尼松龙对初始毒血症显示出保护作用。然而，到第7天，保护作用不再明显，类固醇促进了腹腔内细菌的存活。根据皮质类固醇在治疗百日咳中的有益作用的报道以及HLT在该疾病发病机制中的可能作用，对这些发现进行了讨论。
