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[心肌梗死伴非阻塞性冠状动脉病变的病理生理学及诊断与治疗流程]

[Pathophysiology and diagnostic and therapeutic algorithm of MINOCA].

作者信息

Ricarte-Bratti Juan Pablo, Bono Julio Oscar Emilio, Barcudi Raul

机构信息

Universidad Nacional de Córdoba.

Sanatorio Allende.

出版信息

Rev Fac Cien Med Univ Nac Cordoba. 2023 Mar 31;80(1):36-42. doi: 10.31053/1853.0605.v80.n1.36817.

DOI:10.31053/1853.0605.v80.n1.36817
PMID:37018364
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10142673/
Abstract

MINOCA is a syndrome that encompasses several pathologies and occurs in the clinical context of an Acute Coronary Syndrome. Its incidence varies according to the population studied, the diagnostic methods used and whether they have included Myocarditis and Takotsubo Syndrome, which were recently excluded from the definition of MINOCA. For this reason, we consider that the novelty of this publication is the non-inclusion of these two pathologies and, therefore, the objective of this review is to update this syndrome concisely. The management of the three types of MINOCA is also addressed, whose diagnosis is mainly based in using specific complementary images, since coronary angiography has its limitations. Treatment will generally be pharmacological according to the pathophysiological mechanism involved.

摘要

心肌梗死伴非阻塞性冠状动脉病变(MINOCA)是一种包含多种病理情况的综合征,发生于急性冠状动脉综合征的临床背景下。其发病率因所研究的人群、使用的诊断方法以及是否纳入心肌炎和应激性心肌病(最近已从MINOCA的定义中排除)而有所不同。因此,我们认为本出版物的新颖之处在于未纳入这两种病理情况,所以本综述的目的是简要更新这一综合征。还讨论了三种类型的MINOCA的管理,其诊断主要基于使用特定的辅助影像,因为冠状动脉造影有其局限性。治疗通常会根据所涉及的病理生理机制采用药物治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8f9/10142673/820e53d829e9/1853-0605-80-1-036-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8f9/10142673/a32a2d1fd1b8/1853-0605-80-1-036-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8f9/10142673/d57ae1236718/1853-0605-80-1-036-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8f9/10142673/820e53d829e9/1853-0605-80-1-036-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8f9/10142673/a32a2d1fd1b8/1853-0605-80-1-036-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8f9/10142673/d57ae1236718/1853-0605-80-1-036-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8f9/10142673/820e53d829e9/1853-0605-80-1-036-g003.jpg

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本文引用的文献

1
Survival in Patients With Suspected Myocardial Infarction With Nonobstructive Coronary Arteries: A Comprehensive Systematic Review and Meta-Analysis From the MINOCA Global Collaboration.非阻塞性冠状动脉疾病疑似心肌梗死患者的生存情况:MINOCA 全球协作的综合系统评价和荟萃分析。
Circ Cardiovasc Qual Outcomes. 2021 Nov;14(11):e007880. doi: 10.1161/CIRCOUTCOMES.121.007880. Epub 2021 Nov 16.
2
Refining the Role of CMR Imaging in MINOCA.优化心脏磁共振成像在心肌梗死伴非阻塞性冠状动脉病变中的作用
JACC Cardiovasc Imaging. 2021 Sep;14(9):1784-1786. doi: 10.1016/j.jcmg.2021.03.024. Epub 2021 May 19.
3
Prognostic Value of GRACE Risk Scores in Patients With Non-ST-Elevation Myocardial Infarction With Non-obstructive Coronary Arteries.
GRACE风险评分在非ST段抬高型心肌梗死合并非阻塞性冠状动脉疾病患者中的预后价值
Front Cardiovasc Med. 2021 Feb 16;8:582246. doi: 10.3389/fcvm.2021.582246. eCollection 2021.
4
MINOCA: a heterogenous group of conditions associated with myocardial damage.MINOCA:一组与心肌损伤相关的异质性疾病。
Heart. 2021 Sep;107(18):1458-1464. doi: 10.1136/heartjnl-2020-318269. Epub 2021 Feb 10.
5
Antiplatelet therapy in patients with myocardial infarction without obstructive coronary artery disease.心肌梗死且无阻塞性冠状动脉疾病患者的抗血小板治疗。
Heart. 2021 Nov;107(21):1739-1747. doi: 10.1136/heartjnl-2020-318045. Epub 2021 Jan 27.
6
Myocardial infarction with non-obstructive coronary arteries (MINOCA): Intracoronary imaging-based diagnosis and management.非阻塞性冠状动脉心肌梗死(MINOCA):基于冠状动脉内影像学的诊断和治疗。
J Cardiol. 2021 May;77(5):444-451. doi: 10.1016/j.jjcc.2021.01.001. Epub 2021 Jan 16.
7
Myocardial Infarction Without Obstructive Coronary Artery Disease (MINOCA): A Practical Guide for Clinicians.无阻塞性冠状动脉疾病的心肌梗死(MINOCA):临床医生实用指南。
Curr Probl Cardiol. 2021 Mar;46(3):100761. doi: 10.1016/j.cpcardiol.2020.100761. Epub 2020 Dec 10.
8
The Imaging Toolbox to Assess Patients with Suspected Myocardial Infarction in the Absence of Obstructive Coronary Artery Disease (MINOCA).用于评估疑似非阻塞性冠状动脉疾病(MINOCA)心肌梗死患者的成像工具包。
Curr Cardiol Rep. 2020 Sep 10;22(11):134. doi: 10.1007/s11886-020-01379-x.
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Coronary Microvascular Dysfunction.冠状动脉微血管功能障碍
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