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有无对比纳米颗粒情况下胃癌细胞对宽带太赫兹辐射反应的统计分析

Statistical Analysis of Gastric Cancer Cells Response to Broadband Terahertz Radiation with and without Contrast Nanoparticles.

作者信息

Schreiner Oliver Daniel, Socotar Diana, Ciobanu Romeo Cristian, Schreiner Thomas Gabriel, Tamba Bogdan Ionel

机构信息

Department of Electrical Measurements and Materials, Gheorghe Asachi Technical University, 700050 Iasi, Romania.

CEMEX-Center for Experimental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700259 Iasi, Romania.

出版信息

Cancers (Basel). 2024 Jul 4;16(13):2454. doi: 10.3390/cancers16132454.

DOI:10.3390/cancers16132454
PMID:39001516
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11240478/
Abstract

The paper describes the statistical analysis of the response of gastric cancer cells and normal cells to broadband terahertz radiation up to 4 THz, both with and without the use of nanostructured contrast agents. The THz spectroscopy analysis was comparatively performed under the ATR procedure and transmission measurement procedure. The statistical analysis was conducted towards multiple pairwise comparisons, including a support medium (without cells) versus a support medium with nanoparticles, normal cells versus normal cells with nanoparticles, and, respectively, tumor cells versus tumor cells with nanoparticles. When generally comparing the ATR procedure and transmission measurement procedure for a broader frequency domain, the differentiation between normal and tumor cells in the presence of contrast agents is superior when using the ATR procedure. THz contrast enhancement by using contrast agents derived from MRI-related contrast agents leads to only limited benefits and only for narrow THz frequency ranges, a disadvantage for THz medical imaging.

摘要

本文描述了胃癌细胞和正常细胞对高达4太赫兹的宽带太赫兹辐射的响应的统计分析，包括使用和不使用纳米结构造影剂的情况。太赫兹光谱分析是在衰减全反射（ATR）程序和透射测量程序下进行比较的。对多个成对比较进行了统计分析，包括支撑介质（无细胞）与含纳米颗粒的支撑介质、正常细胞与含纳米颗粒的正常细胞，以及肿瘤细胞与含纳米颗粒的肿瘤细胞。在更宽的频域中总体比较ATR程序和透射测量程序时，使用ATR程序时，在存在造影剂的情况下，正常细胞和肿瘤细胞之间的区分更优。使用源自磁共振成像（MRI）相关造影剂的造影剂实现的太赫兹对比度增强仅带来有限的益处，且仅适用于狭窄的太赫兹频率范围，这对太赫兹医学成像来说是一个缺点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/1eee4640e5e2/cancers-16-02454-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/45402fa021dc/cancers-16-02454-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/72dcfaed8f11/cancers-16-02454-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/8a16fbb6ddbc/cancers-16-02454-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/fac34a416a37/cancers-16-02454-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/e5f84f7c65b2/cancers-16-02454-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/a40651352ea7/cancers-16-02454-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/c00615703d80/cancers-16-02454-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/72fafd77b474/cancers-16-02454-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/ab97f5d05102/cancers-16-02454-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/6ce42b95c443/cancers-16-02454-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/a523d0a7e3b6/cancers-16-02454-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/43b79f3090ca/cancers-16-02454-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/eca929234535/cancers-16-02454-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/6f6c3eb06e72/cancers-16-02454-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/c29ae1303c65/cancers-16-02454-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/5a8d4199307d/cancers-16-02454-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/ba8bcfa0c71d/cancers-16-02454-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/2d513aafb676/cancers-16-02454-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/1eee4640e5e2/cancers-16-02454-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/45402fa021dc/cancers-16-02454-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/72dcfaed8f11/cancers-16-02454-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/8a16fbb6ddbc/cancers-16-02454-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/fac34a416a37/cancers-16-02454-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/e5f84f7c65b2/cancers-16-02454-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/a40651352ea7/cancers-16-02454-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/c00615703d80/cancers-16-02454-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/72fafd77b474/cancers-16-02454-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/ab97f5d05102/cancers-16-02454-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/6ce42b95c443/cancers-16-02454-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/a523d0a7e3b6/cancers-16-02454-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/43b79f3090ca/cancers-16-02454-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/eca929234535/cancers-16-02454-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/6f6c3eb06e72/cancers-16-02454-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/c29ae1303c65/cancers-16-02454-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/5a8d4199307d/cancers-16-02454-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/ba8bcfa0c71d/cancers-16-02454-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/2d513aafb676/cancers-16-02454-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9b7/11240478/1eee4640e5e2/cancers-16-02454-g019.jpg

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本文引用的文献

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Terahertz Imaging and Spectroscopy in Cancer Diagnostics: A Technical Review.太赫兹成像与光谱技术在癌症诊断中的应用：技术综述
BME Front. 2020 Sep 25;2020:2547609. doi: 10.34133/2020/2547609. eCollection 2020.
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Optimal frequency determination for terahertz technology-based detection of colitis-related cancer in mice.基于太赫兹技术的结肠炎相关癌症在小鼠中检测的最佳频率确定。
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Lancet Reg Health West Pac. 2023 Mar 11;35:100741. doi: 10.1016/j.lanwpc.2023.100741. eCollection 2023 Jun.
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Super-resolution THz endoscope based on a hollow-core sapphire waveguide and a solid immersion lens.基于空芯蓝宝石波导和固体浸没透镜的太赫兹超分辨率内窥镜。
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