Dermatology Unit. Hospital Universitario Virgen de Las Nieves, IBS Granada, Granada, Spain,
Urticaria Clinic, Hospital Universitario Virgen de Las Nieves, Granada, Spain.
Dermatology. 2023;239(4):601-608. doi: 10.1159/000530518. Epub 2023 Apr 5.
Chronic spontaneous urticaria (CSU) has been associated with poor quality of life and mood disturbances. However, factors associated with these dimensions have not been properly assessed. Moreover, there is a lack of studies regarding sexual dysfunction (SxD) and CSU. Therefore, the aims of this study were to assess quality of life associated factors and to evaluate the prevalence and potential impact of SxD in patients with CSU.
Cross-sectional study of patients suffering from CSU. Sociodemographic and disease activity variables, quality of life, sleep, SxD, anxiety, and depression were collected using validated questionnaires.
Seventy-five patients were included, with a female-to-male ratio of 2.40. Female sex, worse disease control, and sexual dysfunction were associated with poor quality-of-life indexes (p < 0.001). SxD was detected in 52% of female and 63% of male patients. SxD was associated with poor disease control (p < 0.001). Female SxD, but not male, was associated with poorer quality of life (p = 0.02) and an increased risk for anxiety 85% and depression 90% (p < 0.05).
Female patients and those with an inadequate control of CSU are in higher risk of having poorer quality of life. SxD seems to be frequent in patients with CSU. Moreover, female SxD seems to have a more profound impact on quality of life and mood disturbances when compared to males. Assessment of SxD in Urticaria Clinic might be of benefit to identify patients at a higher risk of poor quality of life.
慢性自发性荨麻疹（CSU）与生活质量下降和情绪障碍有关。然而，这些方面的相关因素尚未得到适当评估。此外，关于性功能障碍（SxD）和 CSU 的研究也很少。因此，本研究的目的是评估与生活质量相关的因素，并评估 CSU 患者 SxD 的患病率和潜在影响。
对患有 CSU 的患者进行横断面研究。使用经过验证的问卷收集社会人口统计学和疾病活动变量、生活质量、睡眠、SxD、焦虑和抑郁。
共纳入 75 例患者，男女比例为 2.40。女性性别、疾病控制较差和性功能障碍与生活质量指数较差相关（p < 0.001）。52%的女性和 63%的男性患者存在 SxD。SxD 与疾病控制不佳相关（p < 0.001）。女性 SxD 与生活质量较差相关（p = 0.02），焦虑风险增加 85%，抑郁风险增加 90%（p < 0.05），而男性 SxD 则无此相关性。
女性患者和疾病控制不佳的患者生活质量较差的风险更高。CSU 患者中 SxD 似乎很常见。此外，与男性相比，女性 SxD 似乎对生活质量和情绪障碍的影响更为深远。在荨麻疹诊所评估 SxD 可能有助于识别生活质量较差风险较高的患者。
